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SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma

By David Wrench, Pamela Leighton, Christine F. Skibola, Lucia Conde, Jean-Baptiste Cazier, Janet Matthews, Sameena Iqbal, Emanuela Carlotti, Csaba Bödör, Silvia Montoto, Maria Calaminici, John G. Gribben, T. Andrew Lister and Jude Fitzgibbon

Abstract

Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10−9) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index

Topics: Lymphoid Neoplasia
Publisher: American Society of Hematology
OAI identifier: oai:pubmedcentral.nih.gov:3062316
Provided by: PubMed Central
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