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Pharmacological and clinical overview of cloperastine in treatment of cough

By Maria Antonietta Catania and Salvatore Cuzzocrea

Abstract

Cough constitutes an impressive expression of the normal defense mechanisms of the respiratory system. Productive cough associated with catarrh is an important protective system for the lung because it favors the upward movement of secretions and foreign bodies to the larynx and mouth. Cough may also appear without bronchial secretions, as dry cough, which may be persistent when inflammatory disease is chronic or when, in the early stages of respiratory disease, bronchial secretions are not yet fluid. Sometimes bronchitis-induced cough does not significantly affect quality of life, whilst in other cases cough may become so intense as to impair daily activities severely, resulting in permanent disability. This type of cough is one of the most frequent reasons for seeking medical advice. The use of cough suppressants may be appropriate for reaching a precise diagnosis and when dry cough is persistent. Cloperastine has been investigated in various types of cough and, unlike codeine, has been shown to possess dual activity. It also acts as a mild bronchorelaxant and has antihistaminic activity, without acting on the central nervous system or the respiratory center. Here we review the preclinical and clinical evidence of the efficacy and tolerability of cloperastine

Topics: Review
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:3061847
Provided by: PubMed Central

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Citations

  1. Acute dystonia in a child associated with therapeutic ingestion of a dextromethorphan containing cough and cold syrup.
  2. (2000). Acute dystonia in a young schizophrenic patient associated with ingestion of a cloperastine containing cough syrup. Parkinsonism Relat Disord.
  3. (1996). Bullous mastocytosis in an infant associated with the use of a nonprescription cough suppressant. Pediatr Dermatol.
  4. Clinical trials with the new antitussive levodropropizine in adult bronchitic patients.
  5. Cloperastine ( Nitossil) in the treatment of barking cough in children. Acta Paediatr.1984;
  6. (1981). Cloperastine (Z15042) in the treatment of cough in patients with exacerbated COPD: Controlled clinical study. Medical Praxis.
  7. (1988). Cloperastine fendizoate in the treatment of coughproducing diseases in pediatrics. Minerva Pediatr.
  8. (1983). Cloperastine in chronic bronchopulmonary diseases. Eur Rev Med Pharmacol Sci.
  9. (1983). Cloperastine in the treatment of cough. Eur Rev Med P harmacol Sci.
  10. Cloperastine in the treatment of p ersistent chronic cough. A controlled clinical study.
  11. Cloperastine in the treatment of persistent chronic cough: A controlled clinical study.
  12. Cloperastine syrup (Seki) in the treatment of cough in children. Aggiornamento Pediatrico.
  13. (1987). Cloperastine versus codeine: Controlled clinical study in outpatients with cough of various origin. Pro Med Arztl Ref.
  14. (1992). Comparison of pediatric poisoning hazards: An analysis of 3.8 million exposure incidents. A report from the American Association of Poison Control Centers. Pediatrics.
  15. (2009). Cough and cold remedies for children. Australian Prescriber.
  16. Dextromethorphan abuse.
  17. (2005). Disease Control and Prevention. Infant deaths associated with cough and cold medications – two states,
  18. (1987). Double blind investigation of the antitussive effectiveness of cloperastine. Curr Ther Res.
  19. Effect of cloperastine on mucociliary clearance. Arch Monaldi.
  20. Effect of dextrometorphan, diphenhydramine, and placebo on nocturnal sleep quality for coughing children and their parents.
  21. Efficacy and tolerability of cloperastine fendizoate in the treatment of different etiology chronic cough.
  22. Evaluation of nebulized acetylcysteine and normal saline in the treatment of sputum retention following thoracotomy.
  23. (2004). L evocloperastine in the treatment of chronic nonproductive cough: Comparative efficacy versus standard antitussive agents. Drugs Exp Clin Res.
  24. Lung protection by a thiolcontaining antioxidant:
  25. Nitossil: A new antitussive. A controlled paediatric study. Aggiornamento Pediatrico.
  26. (2007). Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev.
  27. (2001). Over-the-counter medication in children: Friend or foe? Australian Prescriber.
  28. (2008). Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev.
  29. P amparano F. Clinical study of a new drug: Cloperastin. Arch Monaldi.
  30. placebo-controlled study of cloperastine, a new antitussive. Rassegna di Fisiopatologia, Clinica e Riabilitazione Cardiorespiratoria.
  31. Some less familiar drugs of abuse.
  32. Studies on antitussives. IV . Various drugs and ω-(diphenilmetoxy) alkylamine compounds.