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Coexpression of MUC1 with p53 or MUC2 correlates with lymph node metastasis in colorectal carcinomas.

By Kee Taek Jang, Seoung Wan Chae, Jin Hee Sohn, Hye Rim Park and Hyung Sik Shin


The alteration of the mucin profile have been known to play a role in colorectal carcinogenesis. MUC1 is up-regulated and MUC2 is down-regulated in colorectalcarcinomas. Overexpression of p53 is frequently noted in colorectal carcinomas with deep invasion or lymph node metastasis. However, there have been few reports about the association between MUC1, MUC2, and p53 expression with respect to the metastatic potential. This study was aimed to investigate the relationship of MUC1, MUC2, and protein p53 expressions with clinicopathological factors in colorectal carcinomas. Expressions of MUC1, MUC2, and p53 protein were examined immunohistochemically. Of total 97 cancers, 44 (45%) were MUC1 positive, 39 (40%) were MUC2 positive and 58 (59%) showed a p53 overexpression. Coexpression of MUC1 with p53 and dual expression of MUC1 with MUC2 were associated with a higher frequency of lymph node metastasis (p<0.05). The right colon showed a higher MUC1 positivity and frequent lymph node metastasis than the left colon (p<0.05). These results suggest that the coexpression of MUC 1 with p53 or MUC2 are involved in regional lymph node metastasis in colorectal carcinomas. The high expression of MUC1 in the right colon cancer was revealed to relate with lymph node metastasis

Topics: Research Article
Publisher: Korean Academy of Medical Sciences
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Provided by: PubMed Central

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  1. (1997). Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). Fertil Steril
  2. (1994). An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms.
  3. (1994). Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).
  4. (1990). Cloning and sequencing of a human pancreatic mucin cDNA.
  5. (1993). Colorectal cancer metastasis determined by carbohydrate-mediated cell adhesion: role of sialyl-Lex antigens. Semin Cancer Biol
  6. (1995). de Velde CJ, Melief CJ. Antibodies against p53 are associated with poor prognosis of colorectal cancer.
  7. (1995). Diversity of mucin genes, structure, function, and expression. Gastroenterology
  8. (1999). Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma. Hepatology
  9. (1994). Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types.
  10. (1993). Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res
  11. (1993). Human gastric mucin. Identification of a unique species by expression cloning.
  12. (1990). Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.
  13. (1990). Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. Biochem Biophys Res Commun
  14. (1993). Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7).
  15. (1991). MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism.
  16. (1994). MUC1 mucin expression as a marker of pregression and metastasis of human colorectal carcinoma. Gastroenterology
  17. (1993). Mucin glycoproteins in gastrointestinal malignancies and metastasis.
  18. (1992). Mucins bearing the cancerassociated sialosyl-Tn antigen mediate inhibition of natural killer cell cytotoxicity. Cancer Res
  19. (1985). Mucosubstance histochemistry of normal mucosa and carcinoma of the large intestine. Galactose oxidase-Schiff reaction and lectin stainings. Acta Pathol Jpn
  20. (1987). Mucosubstance histochemistry of the human large intestine. Rinsho Byori
  21. (1997). Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary.
  22. (1996). p53 expression in colorectal cancer: relation to tumor type, DNA ploidy pattern and short-term survival.
  23. (1991). p53 expression in colorectal tumors.
  24. (1995). Prognostic significance of MUC1 epithelial mucin expression in breast cancer. Human Pathol
  25. (1990). Sialomucin and lytic susceptibility of rat mammary tumor ascites cells. Cancer Res
  26. (1990). Soluble factor in normal tissues that stimulates high-molecular-weight sialoglycoprotein production by human colon carcinoma cells. Cancer Res
  27. (1996). Ulcerative colitis with overexpression of p53 preceding overt histological abnormalities of the epithelium.