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Sebaceous carcinoma of the eyelids: frequent expression of c-erbB-2 oncoprotein.

By K. J. Cho, S. K. Khang, J. S. Koh, J. H. Chung and S. S. Lee


Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented

Topics: Research Article
Publisher: Korean Academy of Medical Sciences
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Provided by: PubMed Central

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