Article thumbnail

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models

By Helen M. McGuire, Stacey Walters, Alexis Vogelzang, Carol M.Y. Lee, Kylie E. Webster, Jonathan Sprent, Daniel Christ, Shane Grey and Cecile King
Topics: Immunology and Transplantation
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:3046847
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. A critical role for IL-21 in regulating immunoglobulin production.
  2. A fundamental role for interleukin-21 in the generation of T follicular helper cells.
  3. A vital role for interleukin-21 in the control of a chronic viral infection.
  4. Altered effector CD4+ T cell function in IL21R-/- CD4+ T cell-mediated graft-versus-host disease.
  5. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.
  6. (1996). B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new “speed congenic” stock of NOD.Ig mu null mice.
  7. Beta cell apoptosis in T cellmediated autoimmune diabetes.
  8. Blockade of the interleukin-21/ interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.
  9. (1999). Cellular and molecular changes accompanying the progression from insulitis to diabetes.
  10. Clinical islet transplantation: advances and immunological challenges.
  11. Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.
  12. (1997). Diabetes results from a late change in the autoimmune response of NOD mice.
  13. (1996). Dual functional effects of interleukin-1beta on purine nucleotides and insulin secretion in rat islets and INS-1 cells. Diabetes
  14. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.
  15. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.
  16. (1998). IL-1 produced and released endogenously within human islets inhibits beta cell function.
  17. IL-21 blockade reduces graft-versushost disease mortality by supporting inducible T regulatory cell generation.
  18. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21.
  19. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.
  20. IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response.
  21. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
  22. IL-21 is critical for GVHD in a mouse model.
  23. IL-21 is required to control chronic viral infection.
  24. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
  25. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse.
  26. IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells.
  27. (2009). IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science
  28. Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses.
  29. (1990). Insulin independence after islet transplantation into type I diabetic patient. Diabetes
  30. Interleukin 21: a cytokine/cytokine receptor system that has come of age.
  31. Interleukin-21: an interleukin-2 dependent player in rejection processes.
  32. (2008). Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol
  33. (1995). Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase.
  34. (1995). Isolation of leukocytes infiltrating the islets of Langerhans of diabetes-prone mice for flow cytometric analysis.
  35. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.
  36. (1997). Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation
  37. (1996). MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes
  38. Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
  39. (2000). Nitric oxide production and Fas surface expression mediate two independent pathways of cytokineinduced murine beta-cell damage. Diabetes
  40. Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.
  41. Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure.
  42. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
  43. Reversal of established autoimmune diabetes by restoration of endogenous beta cell function.
  44. Review of immunosuppressive usage in pancreas transplantation.
  45. RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice.
  46. (2008). Sarvetnick NE. IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms. PLoS ONE
  47. (2011). T cell immunomodulation—the Holy Grail of therapeutic tolerance.
  48. The initiation of autoimmune diabetes.
  49. (1990). The role of CD8+ and CD4+ cells in islet allograft rejection. Transplantation
  50. (1990). Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol
  51. Very slow turnover of beta-cells in aged adult mice.