Article thumbnail

Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism

By Nabila Aboulaich, Patricia C. Chui, John M. Asara, Jeffrey S. Flier and Eleftheria Maratos-Flier
Topics: Metabolism
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:3046836
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization.
  2. (1991). a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.
  3. A novel proteomic approach for specific identification of tyrosine kinase substrates using [ 13C]tyrosine.
  4. A quantitative atlas of mitotic phosphorylation.
  5. An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
  6. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.
  7. cAMP-dependent protein kinase and lipolysis in rat adipocytes: I. cell preparation, manipulation, and predictability in behavior.
  8. (2002). Caveolae: from cell biology to animal physiology. Pharmacol Rev
  9. (1990). Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation.
  10. Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.
  11. (1991). Effects of body fat distribution on regional lipolysis in obesity.
  12. Fate of fat: the role of adipose triglyceride lipase in lipolysis.
  13. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
  14. Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes.
  15. Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy.
  16. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes.
  17. (2011). Lipotransin: a novel docking protein for hormone-sensitive lipase.
  18. (2001). Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science
  19. Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse.
  20. (1989). Mechanisms underlying regional differences in lipolysis in human adipose tissue.
  21. Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes.
  22. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation.
  23. (1998). Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B. Methods
  24. Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase.
  25. Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence.
  26. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.
  27. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function.
  28. Regulation of adiposetissue lipolysis by phosphorylation of hormone-sensitive lipase.
  29. (2007). Regulation of lipolysis in adipocytes. Annu Rev Nutr
  30. Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
  31. Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes: segregation of specific proteins and functions.
  32. Temporal dynamics of tyrosine phosphorylation in insulin signaling.
  33. Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes.
  34. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.