Article thumbnail

Short Communication: Quantitative Proteomic Plasma Profiling Reveals Activation of Host Defense to Oxidative Stress in Chronic SIV and Methamphetamine Comorbidity

By Gurudutt Pendyala, Sunia A. Trauger, Gary Siuzdak and Howard S. Fox

Abstract

The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antixoidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals

Topics: Pathogenesis
Publisher: Mary Ann Liebert, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3045074
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles