Skip to main content
Article thumbnail
Location of Repository

Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia

By Robert Fitzgerald, Claus Lamm, Wolfgang Oczenski, Thomas Stimpfl, Walter Vycudilik and Herbert Bauer

Abstract

Direct current auditory evoked potentials (DC-AEPs) are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated in humans. To assess the potential usefulness of DC-AEPs as an indicator of anesthesia in humans, we performed an explorative study in which DC-AEPs were recorded during propofol and methohexital anesthesia in hu-mans. DC-AEPs were recorded via 22 scalp electrodes in 19 volunteers randomly assigned to receive either propofol or methohexital. DC-AEPs were evoked by binaurally presented 2-s, 60-dB, 800-Hz tones; meas-urements were taken during awake baseline, anesthesia, and emergence. Statistical analysis included analy-sis of variance and discriminant analysis of data acquired during these three conditions. About 500 ms after stimulus presentation, DC-AEPs could be ob-served. These potentials were present only during base-line and emergence—not during anesthesia. Statistically significant differences were found between baseline and anesthesia and between anesthesia and emergence. In conclusion, similar effects, as reported in animal studies of anesthetics on the DC-AEPs, could be observed in anesthetized humans. These results dem-onstrate that DC-AEPs are potentially useful in the assessment of cortical function during anesthesia and might qualify the method for monitoring anesthesia in humans

Topics: Brain Imaging, Clinical Psychology, Neuropharmacology, Neurophysiology, Physiological Psychology
Year: 2001
OAI identifier: oai:cogprints.org:1633
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://cogprints.org/1633/3/an... (external link)
  • http://cogprints.org/1633/ (external link)
  • Suggested articles

    Citations

    1. (1998). Evoked responses in anaesthesia.
    2. Reizkorrelierte Gleichspannungs-änderungen der primären. Hörrinde an der wachen Katze. Pflügers Arch 1969;306:281–9.
    3. (1971). DC-potentials in the auditory response in man.
    4. (1985). hand and brain: the right shift theory.
    5. (1989). Technical requirements for high-quality scalp DC recordings. Electroencephalogr Clin Neurophysiol
    6. (1998). Slow potential topography.
    7. (1997). Cortical activity of good and poor spatial test performers during spatial and verbal processing studied with slow potential topography.
    8. (1987). The continuing problem of false positives in repeated measures ANOVA in psychophysiology: a multivariate solution. Psychophysiology
    9. On methods in the analysis of profile data.
    10. (1981). A priori tests in repeated measures designs: effects of nonsphericity. Psychometrika
    11. Currents of the human auditory cortex in the cat.
    12. (1978). Human auditory sustained potentials. I. The nature of the response. Electroencephalogr Clin Neurophysiol
    13. Principles of electric response audiometry.
    14. Brain potentials evoked by acoustic stimuli. In:
    15. (1986). Evoked potentials during isoflurane anaesthesia.
    16. (1987). Effect of the acute administration of high dose pentobarbital on human brain stem auditory and median nerve somatosensory evoked responses.
    17. Monitoring depth of anesthesia.
    18. (1996). Midlatency auditory evoked potentials as indicators of perceptual processing during general anesthesia.
    19. (1997). Midlatency auditory evoked potentials and motor signs of wakefulness during anaesthesia with midazolam.
    20. Middle latency auditory evoked potentials during repeated transitions from consciousness to unconsciousness.
    21. (1991). The long-latency auditory evoked potential as a measure of the level of consciousness during sufentanil anesthesia. doi
    22. (1991). Long-latency auditory evoked potentials during general anesthesia: N1 and P3 components. Anesth Analg doi
    23. (1991). The human auditory steadystate evoked potentials. Acta Otolaryngol doi
    24. (1998). Effect of isoflurane on the auditory steady-state response and on consciousness in human volunteers. doi
    25. (1990). Slow potentials of the cerebral cortex and behavior. Physiol Rev
    26. (1998). Contribution of potassium currents and glia to slow potential shifts (SPSs).
    27. Contribution of glia and neurons to the surface-negative potentials of the cerebral cortex during its electrical stimulation. doi

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.