Article thumbnail

Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery

By Basem Abdelmalak, Ankit Maheshwari, Edward Mascha, Sunita Srivastava, Theodore Marks, WH Wilson Tang, Andrea Kurz and Daniel I Sessler
Topics: Study Protocol
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2910009
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2003). A: Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg
  2. (1999). A: Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg
  3. (2001). Adaptive group sequential designs for clinical trials: combining the advantages of adaptive and of classical group sequential approaches. Biometrics
  4. (2004). Association between fasting glucose and C-reactive protein in middle-aged subjects. Diabet Med
  5. (1997). Bengtsson A: Postoperative inflammatory response after autologous and allogeneic blood transfusion. Anesthesiology
  6. (2001). Bistrian BR: Stress-induced hyperglycemia. Crit Care Clin
  7. (2003). C-reactive protein, inflammation, and coronary risk. Cardiol Clin
  8. (2007). Clinical experience with tight glucose control by intensive insulin therapy. Crit Care Med
  9. (2003). Confirmation that Low Intraoperative BIS Levels Predict Increased Risk of Post-Operative Mortality [abstract]. Anesthesiology
  10. (2007). Conte MS: Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery. J Vas Surg
  11. (2002). Corticosteroids and cardiopulmonary bypass: a review of clinical investigations. Chest
  12. Corticosteroids. In The Pharmacologic Approach to the Critically Ill Patient Edited by: Chernow B.
  13. (1990). De Cani JS: Group sequential designs using a family of type I error probability spending functions. Stat Med
  14. (2004). Different Creactive protein kinetics in post-operative hip-fractured geriatric patients with and without complications. Gerontology
  15. (2007). Does tight blood glucose control during cardiac surgery improve patient outcome? Ann Intern Med
  16. (2004). Duration at Low Intraoperative BIS Levels was Shorter among One-Year Postoperative Survivors than Non-Survivors: A Case-Controlled Analysis [Abstract]. Anesthesiology
  17. (1999). E: Preoperative high dose methylprednisolone improves patients outcome after abdominal surgery.
  18. (2003). F: Delirium increases morbidity and length of stay after vascular surgery operations. Results of a prospective study. Chirurg
  19. (1982). Fatigue and cardiorespiratory function following abdominal surgery.
  20. (2000). Group Sequential Methods with Applications to Clinical Trials. [electronic resource] Boca Raton: Chapman and Hall/CRC;
  21. (2003). HJ: Limiting myocardial cell injury during cardiopulmonary bypass: are steroids the answer? Crit Care Med
  22. (2005). I: Effect of intraoperative fluid management on outcome after intraabdominal surgery. Anesthesiology
  23. (2002). Inflammation in atherosclerosis.
  24. (2001). Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab
  25. (2001). Intensive insulin therapy in the critically ill patients.
  26. (1992). Intraoperative warming therapies: a comparison of three devices.
  27. (2001). Is insulin an antiinflammatory molecule? Nutrition
  28. (2003). K: Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med
  29. (1997). Kehlet H: Effect of prednisolone on the systemic response and wound healing after colonic surgery. Arch Surg
  30. (2002). Kehlet H: Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications.
  31. Kivlahan DR: Factorial designs in clinical trials: options for combination treatment studies.
  32. (2007). MaMahon MM: Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery: a randomized trial. Ann Intern Med
  33. (2002). Maseri A: Risk of myocardial infarction and angina in patients with severe peripheral vascular disease: predictive role of C-reactive protein. Circulation
  34. (2005). MM: Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc
  35. (2000). Munck AU: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev
  36. (2005). Perioperative mortality. Risk factors associated with anaesthesia. Przegl Lek
  37. (2001). Postoperative delirium. Med Clin North Am
  38. (2003). Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy: a randomized double-blind placebo-controlled trial. Ann Surg
  39. (2001). Release of pro-and anti-inflammatory cytokines during different anesthesia procedures. Anaesthesiol Reanim
  40. (2006). Sebel P: Relationship between Hypnotic Depth and PostOperative C-Reactive Protein Levels [Abstract]. Anesthesiology
  41. (2005). Sigl JC: Anesthetic management and oneyear mortality after noncardiac surgery. Anesth Analg
  42. (2003). SL: Prognostic value of myeloperoxidase in patients with chest pain.
  43. (2003). Study Group on Perioperative Fluid Therapy: Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg
  44. (1997). Systemic inflammatory response syndrome. BrJ Surg
  45. (1995). TA: Postoperative delirium. A review of 80 primary data-collection studies.
  46. (1996). Tateo I: Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery.
  47. (1997). The Design and Analysis of Sequential Clinical Trials 2nd edition.
  48. (2000). The stress response to trauma and surgery.
  49. (2002). Werb Z: Inflammation and cancer.
  50. (2005). Wouters PJ: Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology