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Changes in creatine transporter function during cardiac maturation in the rat

By Alexandra Fischer, Michiel ten Hove, Liam Sebag-Montefiore, Helga Wagner, Kieran Clarke, Hugh Watkins, Craig A Lygate and Stefan Neubauer
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1984). A: Development of enzymes of energy metabolism in rat heart. Biol Neonate
  2. (1994). AW: Developmental expression of sarcomeric and ubiquitous mitochondrial creatine kinase is tissue-specific. Biochim Biophys Acta
  3. (2005). Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. BMC Dev Biol
  4. (2003). Creatine transporter activity and content in the rat heart supplemented and depleted of creatine.
  5. (2001). Creatine transporter and mitochondrial creatine kinase protein content in myopathies. Muscle Nerve
  6. (2008). Creatine uptake in mouse hearts with genetically altered creatine levels.
  7. (1985). CT: Metabolism during fetal life: a functional assessment of metabolic development. Physiol Rev
  8. (1976). Development and adaptation of heart mitochondria respiratory chain function in fetus and newborn. Exp Med Biol
  9. (1975). Developmental changes in creatine phosphokinase isoenzymes in neonatal mouse hearts.
  10. (2009). Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse.
  11. (1994). Enzymatic method for quantitating lactate dehydrogenase isoenzyme composition in cardiac tissue: utilization of the method to characterize newborn and adult rat heart. Methods Find Exp Clin Pharmacol
  12. (1995). Ertl G: Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction.
  13. (1983). Fossel ET: Developmental changes in creatine kinase metabolism in rat brain.
  14. (1981). Friedman WF: Maturation of energy metabolism in the lamb: changes in myosin ATPase and creatine kinase activities. Pediatr Res
  15. (2001). Functional aspects of creatine kinase isoenzymes in endothelial cells.
  16. (2003). Heerschap A: Presence of (phospho)creatine in developing and adult skeletal muscle of mice without mitochondrial and cytosolic muscle creatine kinase isoforms.
  17. (1982). HG: Perinatal changes in mitochondrial respiration of the rabbit heart. Biol Neonate
  18. (2009). Ilundain AA: Ontogeny regulates creatine metabolism in rat small and large intestine.
  19. (2007). Ilundáin AA: Ontogeny up-regulates renal Na(+)/Cl(-)/creatine transporter in rat. Biochim Biophys Acta
  20. (1988). Ingwall JS: Velocity of the creatine kinase reaction in the neonatal rabbit heart: role of mitochondrial creatine kinase. Biochemistry
  21. (1992). Itoi T: Developmental changes in energy substrate use by the heart. Cardiovascular Research
  22. (1982). JH: Postnatal development of palmitate oxidation and mitochondrial enzyme activities in rat cardiac and skeletal muscle. Biochem Biophys Acta
  23. (2000). Kaddurah Daouk R: Creatine and creatinine metabolism. Physiol Rev
  24. (1991). LA: Postnatal changes in heart mitochondrial calcium and energy metabolism.
  25. (1989). Little C: Phospholipase Cevoked glycerol release in energy depleted rat myocardial cells. Mol Cell Biochem
  26. (1986). Mitochondrial component of the phosphorylcreatine shuttle is enhanced during rat heart perinatal development. Biochem Biophys Res Commun
  27. (1993). MW: A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression.
  28. (2000). PH: Developmental changes in organic osmolytes in prenatal and postnatal rat tissues. Comp Biochem Physiol A Mol Integr Physio
  29. (1987). Phosphorylcreatine shuttle enzymes during perinatal heart development.
  30. PJR: Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalzed after recovery. Circulation 2006, 114(Suppl I):I16-I20.
  31. (1988). Principles of fuel metabolism in heart muscle.
  32. RJ: Protein measurement with the Folin reagent.
  33. (1998). S: Effects of chronic dietary creatine feeding on cardiac energy metabolism and on creatine content in heart, skeletal muscle brain, liver and kidney.
  34. (2005). S: Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferaseknockout mice. Circulation
  35. (1980). Seifter S: Uptake of creatine by cultured cells. Arch Biochem Biophys
  36. (1989). Substrate and energy metabolism of the heart.
  37. (1985). VA: Hormone regulation of cardiac energy metabolism. I. Creatine transport across cell membranes of euthyroid and hyperthyroid rat heart. Biochem Med
  38. (1991). Ventura-Clapier R: Functional development of the creatine kinase system in perinatal rabbit heart. Circ Res
  39. (2004). Wallimann T: Creatine transporters: a reappraisal. Mol Cell Biochem
  40. WF: Developmental changes in heart creatine kinase.