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TBC-2 Regulates RAB-5/RAB-7-mediated Endosomal Trafficking in Caenorhabditis elegans

By Laëtitia Chotard, Ashwini K. Mishra, Marc-André Sylvain, Simon Tuck, David G. Lambright and Christian E. Rocheleau


The RAB-5 and RAB-7 GTPases regulate endosome to lysosome trafficking. Here, we show that Caenorhabditis elegans TBC-2 functions as a RAB-5 GAP. TBC-2 colocalizes with RAB-7 on late endosomes, and requires RAB-7 for membrane localization where TBC-2 could function to antagonize RAB-5 activity during early to late endosome maturation

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Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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