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Genetics of Type 1 Diabetes: What's Next?

By Flemming Pociot, Beena Akolkar, Patrick Concannon, Henry A. Erlich, Cécile Julier, Grant Morahan, Concepcion R. Nierras, John A. Todd, Stephen S. Rich and Jørn Nerup
Topics: Perspectives in Diabetes
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:2889752
Provided by: PubMed Central

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  1. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
  2. (1994). A genome-wide search for human type 1 diabetes susceptibility genes.
  3. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
  4. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
  5. (1984). A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes
  6. (1998). A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet
  7. (2009). Analysis of maternaloffspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. Diabetes Obes Metab
  8. Anders Hamsten on behalf of Procardis Consortium,
  9. (2009). Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. Diabetes Obes Metab
  10. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
  11. augmenting and refining genome-wide association signals.
  12. B7/CD28 costimulation is essential for the homeostasis of the CD4CD25 immunoregulatory T cells that control autoimmune diabetes.
  13. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.
  14. Common genetic variation and human traits.
  15. (2009). Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab
  16. (2000). CTLA-4 in autoimmune diseases: a general susceptibility gene to autoimmunity? Genes Immun
  17. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
  18. (2006). Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key. Trends Genet
  19. (2010). Detailed transcriptome atlas of the pancreatic beta cell.
  20. Diabetes: a virus-gene collaboration.
  21. diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.
  22. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.
  23. Eizirik DL. PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
  24. European Consortium for IDDM Studies. A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.
  25. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
  26. (2009). Experimental aspects of copy number variant assays at CCL3L1. Nat Med
  27. (2009). Expression profiling of human genetic and protein interaction networks in type 1 diabetes. PLoS One
  28. Extreme genetic risk for type 1A diabetes.
  29. Finding the missing heritability of complex diseases.
  30. (2003). FinnDiane Study Group. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes: indication of an increased environmental pressure? Diabetologia
  31. Gene map of the extended human MHC.
  32. (2003). Genetic epidemiology of type 1 diabetes. Pediatr Diabetes
  33. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study.
  34. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q.
  35. Genetics of type 1 diabetes mellitus.
  36. Genome-wide association studies for complex traits: consensus, uncertainty and challenges.
  37. (2010). Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  38. (2007). Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes
  39. Guilt beyond a reasonable doubt.
  40. How do regulatory T cells work?
  41. (2009). IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet
  42. Insulin as an autoantigen in NOD/human diabetes.
  43. (1997). Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.
  44. (2007). Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. Genome Biol
  45. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
  46. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
  47. Loss of functional suppression by CD4CD25 regulatory T cells in patients with multiple sclerosis.
  48. (1990). Mapping genes in diabetes: genetic epidemiological perspective. Diabetes
  49. (2009). Mating in parents of type 1 diabetes families as a function of the HLA DR-DQ haplotype. Diabetes Obes Metab
  50. Metaanalysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
  51. (2009). MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes Obes Metab
  52. Network biology: understanding the cell’s functional organization.
  53. (2009). No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia
  54. (2004). not immunity, crucially depends on IL-2. Nat Rev Immunol
  55. (1999). Onset of type 1 diabetes: a dynamical instability. Diabetes
  56. (2009). Overview of the MHC fine mapping data. Diabetes Obes Metab
  57. (2009). Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet
  58. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.
  59. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
  60. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
  61. Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  62. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
  63. (1996). The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet
  64. (1995). The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): implementation of screening and staging of relatives.
  65. The human disease network.
  66. (1997). The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
  67. The MHC sequencing consortium. Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium.
  68. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes.
  69. (2008). The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care
  70. (2008). Type 1 Diabetes Genetics Consortium. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes
  71. (2010). Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.
  72. (2009). Type I Diabetes Genetics Consortium. Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. Genes Immun
  73. (2009). Type I Diabetes Genetics Consortium. Evidence for association of the TCF7 locus with type I diabetes. Genes Immun
  74. (2009). Type I Diabetes Genetics Consortium. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun
  75. (2010). Wellcome Trust Case Control Consortium, Illig
  76. Wellcome Trust Case Control Consortium, Tyler-Smith
  77. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
  78. Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.