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Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

By Satoru Arimitsu and Gerald B Hammond


gem-Difluoro-1,7-enyne amides are suitable building blocks for the synthesis of difluorodihydropyridinones via a ring-closing metathesis reaction, and of 4,4-difluoro-3-oxoisoquinolines through a ring-closing metathesis–enyne metathesis tandem reaction. These products, in turn, undergo a Diels–Alder reaction to yield heterotricyclic systems in moderate to good yields

Topics: Full Research Paper
Publisher: Beilstein-Institut
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Provided by: PubMed Central
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