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Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation

By Marin Barisic, Bénédicte Sohm, Petra Mikolcevic, Cornelia Wandke, Veronika Rauch, Thomas Ringer, Michael Hess, Günther Bonn and Stephan Geley

Abstract

Human Spindly is required for kinetochore localization of cytoplasmic dynein, which is essential for poleward movement of chromosomes and for kinetochore protein streaming. In addition, Spindly controls the activity and kinetochore abundance of the RZZ complex, which contributes to microtubule attachment and mitotic checkpoint activity

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:2883941
Provided by: PubMed Central
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