Article thumbnail

Living on the edge: stress and activation of stress responses promote lifespan extension

By Alice Zuin, David Castellano-Esteve, José Ayté and Elena Hidalgo


Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, sublethal exposure to toxic molecules such as reactive oxygen species can induce cellular responses that result in stress fitness. Studies in Schizosaccharomyces pombe have recently showed that the Sty1 MAP kinase, known to be activated by hydrogen peroxide and other cellular stressors, plays a pivotal role in promoting fitness and longevity when it becomes activated by calorie restriction, a situation which induces oxidative metabolism and reactive oxygen species production. Activation of the MAP kinase by calorie restriction during logarithmic growth induces a transcriptional anti-stress response including genes essential to promote lifespan extension. Importantly enough, the lifespan promotion exerted by deletion of the pka1 or sck2 genes, inactivating the two main nutrient-responsive pathways, is dependent on the presence of a functional Sty1 stress pathway, since double mutants also lacking Sty1 or its main substrate Atf1 do not display extended viability. In this Research Perspective, we review these findings in relation to previous reports and extend important aspects of the original study. We propose that moderate stress levels that are not harmful for cells can make them stronger

Topics: Research Perspective
Publisher: Impact Journals LLC
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. Cellular quiescence: are controlling genes conserved?
  2. Chaudhuri WF, tissue: Dev
  3. Ferbeyre through
  4. Gems "that which does not
  5. Glucose inducing mitochondrial respiration and increasing oxidative stress. 30. Su
  6. Multiple pathways differentially regulate global oxidative
  7. Nielsen and serial
  8. Regulation of chronological aging in
  9. Schizosaccharomyces pombe atf1+ encodes a transcription factor phase.
  10. The Atf1 transcription factor is a target for the
  11. Wei span extension by calorie restriction depends on
  12. Yoshida control
  13. Zuin AP, relies