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A novel biomarker TERTmRNA is applicable for early detection of hepatoma

By Norimasa Miura, Yukio Osaki, Miki Nagashima, Michimori Kohno, Kensho Yorozu, Kohei Shomori, Takamasa Kanbe, Kenji Oyama, Yukihiro Kishimoto, Shigeo Maruyama, Eijiro Noma, Yutaka Horie, Masatoshi Kudo, Seigo Sakaguchi, Yasuaki Hirooka, Hisao Ito, Hironaka Kawasaki, Junichi Hasegawa and Goshi Shiota
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2007). A diagnostic evaluation of serum human telomerase reverse transcriptase mRNA as a novel tumor marker for gynecologic malignancies. Oncol Rep
  2. (1999). AC: Rising incidence of hepatocellular carcinoma in the United States.
  3. (2003). Aoyagi Y: Sensitive and specific detection of circulating cancer cells in patients with hepatocellular carcinoma; detection of human telomerase reverse transcriptase messenger RNA after immunomagnetic separation. Clin Cancer Res
  4. (2003). Arsura M: Inhibition of CK2 activity by TGF-beta 1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes. Hepatology
  5. (2007). Boukamp P: The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
  6. (2003). Cellular distribution of telomerase reverse transcriptase in human hepatocellular carcinoma.
  7. (2007). Circulating cell-free mRNA in plasma as a tumor marker for patients with primary and recurrent gastric cancer. Anticancer Res
  8. (2000). CL: Telomerase activity in peripheral blood for diagnosis of hepatoma.
  9. (2008). Clinical impact of serum transforming growth factor-alpha mRNA as a predictive biomarker for the prognosis of fulminant hepatitis. Hepatol Int
  10. (2002). Clinicopathologic features of patients with hepatocellular carcinoma seropositive for a-fetoprotein-L3 and seronegative for desg-carboxyprothrombin in comparison with those seropositive for desg-carboxy prothrombin alone.
  11. (2006). Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma. Hepatology
  12. (2007). EH: Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell
  13. (2003). Elledge SJ: Multiple tumor suppressor pathways negatively regulate telomerase. Cell
  14. (2008). ENK: Molecular mechanisms of hepatocellular carcinoma. Hepatology
  15. (2006). et al.: Clinical usefulness of serum telomerase reverse transcriptase (hTERT) mRNA and epidermal growth factor receptor (EGFR) mRNA as a novel tumor marker for lung cancer. Cancer Sci
  16. (2000). et al.: Expression of telomerase component genes in hepatocellular carcinoma.
  17. (1999). Expression of the RNA component of human telomerase (hTR) in prostate cancer, prostatic intraepithelial neoplasia, and normal prostate tissue.
  18. (1991). Generalized Norton-Simon models of tumour growth. Stat Med
  19. (2007). GM: Annexin A2 is a soluble mediator of macrophage activation.
  20. (1999). Gocke CD: Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res
  21. (2000). H: Differences in survival based on the type of follow-up for the detection of hepatocellular carcinoma: an analysis of 547 patients. Hepatol Res
  22. (2004). HC: High alphafetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations.
  23. (2006). Heat shock-induced enhancement of osteoblastic differentiation of hTERT-immortalized mesenchymal stem cells.
  24. (2007). Human telomerase is regulated by erythropoietin and
  25. (2007). Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma. Exp Mol Med
  26. (2008). Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38. FASEB J
  27. (2007). Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells. Biol Pharm Bull
  28. (1999). Ito H: Thymidine phosphorylase expression in human colorectal mucosa, adenoma and carcinoma: role of p53 expression. Pathol Int
  29. (1994). JW: Specific association of human telomerase activity with immortal cells and cancer. Science
  30. (1997). Kajiyama G: Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma.
  31. (2006). L: Management of small hepatocellular carcinoma. Acta Gastroenterol Belg
  32. (2002). Lo YM: Presence of filterable and non filterable mRNA in the plasma of cancer patients and healthy individuals. Clin Chem
  33. (2002). Lo YM: Stability of Endogeneous and added RNA in blood specimens, serum, and plasma. Clin Chem
  34. (2000). MF: Dedifferentiation of human hepatocellular carcinoma up-regulates telomerase and Ki-67 expression. Arch Surg
  35. (1997). PJ: Semiquantification of circulating hepatocellular carcinoma cells by reverse transcriptase polymerase chain reaction.
  36. (1997). Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet
  37. (2001). Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel.
  38. (2003). Sensitive detection of hTERTmRNA in the serum of patients with hepatocellular carcinoma. Oncology
  39. (2005). Serum human telomerase reverse transcriptase messenger RNA as a novel tumor marker for hepatocellular carcinoma. Clin Cancer Res
  40. (1996). Sugimachi K: Postoperative hepatitis status as a significant risk factor for recurrence in cirrhotic patients with small hepatocellular carcinoma. Cancer
  41. (1999). Tahara E, Ide T: Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections. Oncogene
  42. (2004). Tang TY: Relationship between microvessel density and telomerase activity in hepatocellular carcinoma.
  43. (2000). Telomerase RNA as a detection marker in the serum of breast cancer patients. Clin Cancer Res
  44. (2007). Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology
  45. (2003). The diagnostic and prognostic relevance of human telomerase reverse transcriptase mRNA expression detected in situ in patients with non small cell lung carcinoma. Cancer
  46. (2006). Tojo A, et al.: Successful immortalization of mesenchymal progenitor cells derived from human placenta and the differentiation abilities of immortalized cells.
  47. (2007). Zaffaroni N: Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment. Biochem Pharmacol
  48. (2003). Zern MA: In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplant