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Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis

By Kevin C Doerschug, Angela S Delsing, Gregory A Schmidt and Alix Ashare
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1999). A: Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock. Shock
  2. (1999). A: Angiotensin II stimulates intercellular adhesion molecule-1 (ICAM-1) expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo. Circulation
  3. (2003). Angiotensin II-induced modulation of endothelium-dependent relaxation in rabbit mesenteric resistance arteries.
  4. (2005). Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature
  5. (1998). Blecher S: Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med
  6. (2009). Characterization of tissue oxygen saturation and the vascular occlusion test: influence of measurement sites, probe sizes and deflation thresholds. Critical Care
  7. (1998). DG: Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis.
  8. (2000). DN: Angiotensin II inhibitor DuP753 attenuates burn- and endotoxin-induced gut ischemia, lipid peroxidation, mucosal permeability, and bacterial translocation. Ann Surg
  9. (2001). Early goal-directed therapy in the treatment of severe sepsis and septic shock.
  10. (2002). Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis.
  11. Effect of angiotensin II on microvascular permeability.
  12. (2001). Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function.
  13. (1998). Enalaprilat improves gut perfusion in critically injured patients. Shock
  14. (2007). GJ: Dynamic nearinfrared spectroscopy measurements in patients with severe sepsis. Shock
  15. (2005). Guidot DM: Angiotensin II mediates glutathione depletion, transforming growth factor-{beta}1 expression, and epithelial barrier dysfunction in the alcoholic rat lung. Am J Physiol Lung Cell Mol Physiol
  16. (2007). Haynes WG: Impairments in microvascular reactivity are related to organ failure in human sepsis.
  17. (2007). Heistad DD: Role of Angiotensin II in Endothelial Dysfunction Induced by Lipopolysaccharide in Mice. Am J Physiol Heart Circ Physiol
  18. (1998). Hempelmann G: Influence of angiotensin-converting enzyme inhibitor enalaprilat on endothelialderived substances in the critically ill. Crit Care Med
  19. (2006). How can the response to volume expansion in patients with spontaneous respiratory movements be predicted?. Crit Care
  20. (2006). Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network: Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury.
  21. (2002). JL: Microvascular blood flow is altered in patients with sepsis.
  22. (2001). JL: Serial evaluation of the SOFA score to predict outcome in critically ill patients. Jama
  23. (2008). JL: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock:
  24. (2007). JL: The prognostic value of muscle StO(2) in septic patients. Intensive Care Med
  25. (1994). JR: Validation of near-infrared spectroscopy in humans.
  26. (2009). Kanoore Edul VS, Palizas F, Estenssoro E, Ince C: Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care
  27. (2006). MH: Comparison of buccal microcirculation between septic and hemorrhagic shock. Crit Care Med
  28. (1991). MH: Peripheral vascular tone in sepsis. Chest
  29. (2005). Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock. Intensive Care Med
  30. (2004). Microvascular resuscitation as a therapeutic goal in severe sepsis. Crit Care 2005, 9(Suppl 4):S27-32. Doerschug et al. Critical Care 2010, 14:R24 Page 8 of 94. Sakr
  31. (2004). MJ: Direct evidence of leukocyte adhesion in arterioles by angiotensin II.
  32. (2005). Mowlem JD: Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative nearinfrared spectroscopy.
  33. (2003). NJ: Acute angiotensin II increases plasma F2-isoprostanes in saltreplete human hypertensives. Free Radic Biol Med
  34. (2002). Oudemans-van Straaten HM, Zandstra DF: Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet
  35. (2000). Piantadosi CA: Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand
  36. (1987). Reninangiotensin system in sepsis. Clin Exp Hypertens A
  37. (2006). Sanz MJ: Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines.
  38. (2008). Schmidt GA: Fluid therapy in resuscitated sepsis: less is more. Chest
  39. (2009). The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med
  40. (1968). Vascular responses to norepinephrine, angiotensin, vasopressin and serotonin. Fed Proc
  41. (1992). WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest