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Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial

By Jolien de Jager, Adriaan Kooy, Philippe Lehert, Michiel G Wulffelé, Jan van der Kolk, Daniël Bets, Joop Verburg, Ab J M Donker and Coen D A Stehouwer


Objectives To study the effects of metformin on the incidence of vitamin B-12 deficiency (<150 pmol/l), low concentrations of vitamin B-12 (150-220 pmol/l), and folate and homocysteine concentrations in patients with type 2 diabetes receiving treatment with insulin

Topics: Research
Publisher: BMJ Publishing Group Ltd.
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Provided by: PubMed Central

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