Article thumbnail

The THO complex as a key mRNP biogenesis factor in development and cell differentiation

By Sonia Jimeno and Andrés Aguilera

Abstract

The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent to be exported from the nucleus, yet its precise function is unknown. A recent study in BMC Biology on the role of the THOC5 subunit in cell physiology and mouse development provides new clues to the role of the THO complex in cell differentiation

Topics: Minireview
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2871528
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2006). An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Mol Cell Biol
  2. (2005). Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Curr Opin Cell Biol
  3. (2006). Dias A and Reed R: Human mRNA export machinery recruited to the 5’ end of mRNA. Cell
  4. (2009). DW: Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Mol Cell Biol
  5. (2006). DW: Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse. Mol Cell Biol
  6. (2010). Georgieva SG: Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Genes Dev
  7. (2004). Izaurralde E: Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol
  8. (2008). Libri D: THO/Sub2p functions to coordinate 3’-end processing with gene-nuclear pore association. Cell
  9. (2005). Recruitment of the human TREX complex to mRNA during splicing. Genes Dev
  10. (2002). Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol
  11. (2009). Structural requirements for the ubiquitin-associated domain of the mRNA export factor Mex67 to bind its specific targets, the transcription elongation THO complex component Hpr1 and nucleoporin FXFG repeats.
  12. (2010). Tamura T: THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.