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The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex

By Vivian Cody, Jim Pace, Lu Lin and Aleem Gangjee


The crystal structure of the Z-isomer of 2,4-diamino-5-[2-(2′-methoxyphenyl)-propenyl]-furo[2,3-d]pyrimidine shows an unusual packing arrangement in which the conserved active site Arg70 forms a salt bridge to the side chain of Glu44 from a symmetry-related molecule

Topics: Structural Communications
Publisher: International Union of Crystallography
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Provided by: PubMed Central
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