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Design and integration of an all-in-one biomicrofluidic chip

By Liyu Liu, Wenbin Cao, Jingbo Wu, Weijia Wen, Donald Choy Chang and Ping Sheng

Abstract

We demonstrate a highly integrated microfluidic chip with the function of DNA amplification. The integrated chip combines giant electrorheological-fluid actuated micromixer and micropump with a microheater array, all formed using soft lithography. Internal functional components are based on polydimethylsiloxane (PDMS) and silver∕carbon black-PDMS composites. The system has the advantages of small size with a high degree of integration, high polymerase chain reaction efficiency, digital control and simple fabrication at low cost. This integration approach shows promise for a broad range of applications in chemical synthesis and biological sensing∕analysis, as different components can be combined to target desired functionalities, with flexible designs of different microchips easily realizable through soft lithography

Topics: Regular Articles
Publisher: American Institute of Physics
OAI identifier: oai:pubmedcentral.nih.gov:2716927
Provided by: PubMed Central
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