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Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes

By Terry J. Gaymes, Sydney Shall, Lee J. MacPherson, Natalie A. Twine, Nicholas C. Lea, Farzin Farzaneh and Ghulam J. Mufti

Abstract

Hematopoietic cells from patients with acute myeloid leukemia and myelodysplastic syndrome often have defects in DNA repair processes. This study shows that these defects make the cells susceptible to induction of apoptosis by poly ADP-ribose polymerase (PARP) inhibitors

Topics: Original Article
Publisher: Ferrata Storti Foundation
OAI identifier: oai:pubmedcentral.nih.gov:2675675
Provided by: PubMed Central
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