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Hippocampal Lesions Impair Rapid Learning of a Continuous Spatial Alternation Task

By Steve M. Kim and Loren M. Frank


The hippocampus is essential for the formation of memories for events, but the specific features of hippocampal neural activity that support memory formation are not yet understood. The ideal experiment to explore this issue would be to monitor changes in hippocampal neural coding throughout the entire learning process, as subjects acquire and use new episodic memories to guide behavior. Unfortunately, it is not clear whether established hippocampally-dependent learning paradigms are suitable for this kind of experiment. The goal of this study was to determine whether learning of the W-track continuous alternation task depends on the hippocampal formation. We tested six rats with NMDA lesions of the hippocampal formation and four sham-operated controls. Compared to controls, rats with hippocampal lesions made a significantly higher proportion of errors and took significantly longer to reach learning criterion. The effect of hippocampal lesion was not due to a deficit in locomotion or motivation, because rats with hippocampal lesions ran well on a linear track for food reward. Rats with hippocampal lesions also exhibited a pattern of perseverative errors during early task experience suggestive of an inability to suppress behaviors learned during pretraining on a linear track. Our findings establish the W-track continuous alternation task as a hippocampally-dependent learning paradigm which may be useful for identifying changes in the neural representation of spatial sequences and reward contingencies as rats learn and apply new task rules

Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  3. (2001). Accumulation of hippocampal place fields at the goal location in an annular watermaze task.
  4. (2006). Behavioral correlates of the distributed coding of spatial context.
  5. (2003). Computational models of the hippocampal region: linking incremental learning and episodic memory.
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  7. (2003). Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats.
  8. (2008). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation.
  9. (2002). Critical role of the hippocampus in memory for sequences of events.
  10. (2007). Disambiguation of overlapping experiences by neurons in the medial entorhinal cortex.
  11. (1997). Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning.
  12. (1999). Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions.
  13. (2004). Dynamic analysis of learning in behavioral experiments.
  14. (1999). Dynamic filtering of recognition memory codes in the hippocampus.
  15. (1993). Dynamics of the hippocampal ensemble code for space.
  16. (2003). Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory.
  17. (1997). Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-potentiated startle.
  18. (1991). Experience-dependent modifications of hippocampal place cell firing.
  19. (2007). Exploring the role of context-dependent hippocampal activity in spatial alternation behavior.
  20. Fanselow MS (2005) Bright light suppresses hyperactivity induced by excitotoxic dorsal hippocampus lesions in the rat.
  21. (2008). Firing rate dynamics in the hippocampus induced by trajectory learning.
  22. (2004). Functional differentiation within the medial temporal lobe in the rat.
  23. (2003). Glutamate-receptor-mediated encoding and retrieval of paired-associate learning.
  24. (2007). Goalrelated activity in hippocampal place cells.
  25. (2007). Gradual changes in hippocampal activity support remembering the order of events.
  26. (2006). Gradual translocation of spatial correlates of neuronal firing in the hippocampus toward prospective reward locations.
  27. (2001). Hippocampal amnesia.
  28. (2007). Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points.
  29. (1995). Hippocampal Formation. In: Paxinos
  30. (1999). Hippocampal lesions interfere with Pavlovian negative occasion setting.
  31. (2000). Hippocampal neurons encode information about different types of memory episodes occurring in the same location.
  32. (2003). Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning.
  33. (2006). Hippocampal place cells, context, and episodic memory.
  34. (2004). Hippocampal plasticity across multiple days of exposure to novel environments.
  35. (2005). Hippocampal replay contributes to within session learning in a temporal difference reinforcement learning model.
  36. (1979). Hippocampus, space, and memory.
  37. (2000). Impaired recognition memory in monkeys after damage limited to the hippocampal region.
  38. (2000). Impaired recognition memory in rats after damage to the hippocampus.
  39. (2001). Impaired recognition of the goal location during spatial navigation in rats with hippocampal lesions.
  40. (2001). Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena.
  41. (1996). Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning.
  42. (2005). Independent codes for spatial and episodic memory in hippocampal neuronal ensembles.
  43. (1995). Interactions between location and task affect the spatial and directional firing of hippocampal neurons.
  44. (2008). Internally generated cell assembly sequences in the rat hippocampus.
  45. (1957). Loss of recent memory after bilateral hippocampal lesions.
  46. (1979). Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
  47. (2005). Microstructure of a spatial map in the entorhinal cortex.
  48. (2001). Minai A
  49. (2008). Network dynamics underlying the formation of sparse, informative representations in the hippocampus.
  50. (2002). Nonparametric Analysis of Longitudinal Data in Factorial Experiments.
  51. (1997). Perseveration on place reversals in spatial swimming pool tasks: further evidence for place learning in hippocampal rats.
  52. (1982). Place navigation impaired in rats with hippocampal lesions.
  53. (2003). Prospective and retrospective memory coding in the hippocampus.
  54. (2008). Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior.
  55. (1993). Recce ML
  56. (2008). Representation of geometric borders in the entorhinal cortex.
  57. (2001). Retrograde amnesia for spatial memory induced by NMDA receptor-mediated long-term potentiation.
  58. (2006). Reverse replay of behavioural sequences in hippocampal place cells during the awake state.
  59. (1999). Reversible neural inactivation reveals hippocampal participation in several memory processes.
  60. (2006). Storage of spatial information by the maintenance mechanism of LTP.
  61. (2003). Strudwick A
  62. (1997). Task-dependent representations in rat hippocampal place neurons.
  63. (2004). The dynamics of spatial behavior: how can robust smoothing techniques help?
  64. (1999). The effects of NMDA-induced retrohippocampal lesions on performance of four Lesions Impair Learning PLoS
  65. (1987). The efficiency of systematic sampling in stereology and its prediction.
  66. (1999). The global record of memory in hippocampal neuronal activity.
  67. (1996). The hippocampus and reward: effects of hippocampal lesions on progressive-ratio responding.
  68. (2004). The Rat Brain in Stereotaxic Coordinates.
  69. (2008). Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus.
  70. (1996). Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation.
  71. (2000). Trajectory encoding in the hippocampus and entorhinal cortex.

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