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Molecular mechanisms of experience-dependent plasticity in visual cortex

By Daniela Tropea, Audra Van Wart and Mriganka Sur


A remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular imaging, combined with genetic manipulations in mice, novel fluorescent recombinant probes, and large-scale screens of gene expression, have revealed multiple molecular mechanisms that underlie structural and functional plasticity in visual cortex. We situate these mechanisms in the context of a new conceptual framework of feed-forward and feedback regulation for understanding how neurons of the visual cortex reorganize their connections in response to changes in sensory inputs. Such conceptual advances have important implications for understanding not only normal development but also pathological conditions that afflict the central nervous system

Topics: Review
Publisher: The Royal Society
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    1. (1988). A cellular analogue of visual cortical plasticity.
    2. (2004). A morphological correlate of synaptic scaling in visual cortex.
    3. (2006). Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex.
    4. (2002). Activity-dependent synaptogenesis in the adult mammalian cortex.
    5. (2002). Anatomical pathways and molecular mechanisms for plasticity in the barrel cortex.
    6. (2006). Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors.
    7. (1998). BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses.
    8. (1965). Binocular interaction in striate cortex of kittens reared with artificial squint.
    9. (2002). Cell typeand input-specific differences in the number and subtypes of synaptic GABA(A) receptors in the hippocampus.
    10. (2000). Columnar distribution of serotonin-dependent plasticity within kitten striate cortex.
    11. (2003). Contribution of acetylcholine to visual cortex plasticity.
    12. (2008). Critical period revisited: impact on vision.
    13. (2006). Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience.
    14. (1999). Development and function of metabotropic glutamate receptors in cat visual cortex.
    15. (2001). Development and plasticity of cortical areas and networks.
    16. (1999). Development of ocular dominance columns in the absence of retinal input.
    17. (1999). Developmental regulation of intracellular calcium by N-methyl-D-aspartate and noradrenaline in rat visual cortex.
    18. (2006). Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex.
    19. (2006). Enhancement of vision by monocular deprivation in adult mice.
    20. (2004). ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons.
    21. (1996). Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse.
    22. (2005). Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.
    23. (1996). Experiencedependent modification of synaptic plasticity in visual cortex.
    24. (1994). Functional postnatal development of the rat primary visual cortex and the role of visual experience: dark rearing and monocular deprivation.
    25. (2008). Gene expression patterns in visual cortex during the critical period: synaptic stabilization and reversal by visual deprivation.
    26. (2007). Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity.
    27. (1995). Inhibition of ocular domimance column formation by infusion of NT-4/5 or BDNF.
    28. (2005). Maturation of GABAergic transmission and the timing of plasticity in visual cortex. Brain Res. Brain Res.
    29. (2004). Microarray analysis of developmental plasticity in monkey primary visual cortex.
    30. (1986). Modulation of visual cortical plasticity by acetylcholine and noradrenaline.
    31. (1990). Molecular and morphological changes in the cat lateral geniculate nucleus and visual cortexinduced byvisual deprivation are revealed by monoclonal antibodies Cat-304 and Cat-301.
    32. (2003). Molecular basis of plasticity in the visual cortex.
    33. (1995). Monocular deprivation decreases the expression of messenger RNA for brainderived neurotrophic factor in the rat visual cortex.
    34. (2006). Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex.
    35. (1992). Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats.
    36. (2003). NMDA receptordependent ocular dominance plasticity in adult visual cortex.
    37. (2005). Ocular dominance plasticity is stably maintained in the absence of alpha calcium calmodulin kinase II (alphaCaMKII) autophosphorylation.
    38. (2007). Persistence of experienceinduced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex.
    39. (2003). Phosphorylation of spinophilin modulates its interaction with actin filaments.
    40. (1973). physiological mechanism for Hebb’s postulate of learning.
    41. (2006). Potentiation of cortical inhibition by visual deprivation.
    42. (2000). Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex.
    43. (2008). Rapid synaptic scaling induced by changes in postsynaptic firing.
    44. (2005). Rearrangement of dendritic spines during short term monocular deprivation in the primary visual cortex of the ferret in vivo.
    45. (2008). Reduced ocular dominance plasticity in the visual cortex of juvenile arc null mice. Neuroscience Meeting Planner,
    46. (2002). Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin.
    47. (2001). Requirement of ERK activation for visual cortical plasticity.
    48. (2006). Structural and functional recovery from early monocular deprivation in adult rats.
    49. (2005). The ability of axons to regenerate their growth cones depends on axonal type and age, and is regulated by calcium, cAMP
    50. (1970). The period of susceptibility to the physiological effects of unilateral eye closure in kittens.
    51. (2008). TNF-alpha is a molecular substrate for activity-dependent scaling of visual responses invivo. Neuroscience Meeting Planner.
    52. (2006). Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors.
    53. (2006). Visual deprivation reactivates rapid ocular dominance plasticity in adult visual cortex.
    54. (1992). Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons.

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