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Mammalian MCM Loading in Late-G1 Coincides with Rb Hyperphosphorylation and the Transition to Post-Transcriptional Control of Progression into S-Phase

By Piyali Mukherjee, Thinh V. Cao, Sherry L. Winter and Mark G. Alexandrow
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

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  2. (1999). Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition.
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  4. (2004). An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.
  5. (1988). Antibodies:
  6. (1992). ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
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  8. (1998). Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
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  10. (1997). Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.
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  14. (1996). Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.
  15. (1998). Cell cycleregulated expression of mammalian CDC6 is dependent on E2F.
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  18. (1999). Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase.
  19. (1993). Cyclins and cyclin-dependent kinases: Take your partners.
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  21. (1988). Differential stability of c-myc mRNAS in a cell-free system.
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  23. (2002). Distinct roles for cyclins E and A during DNA replication complex assembly and activation.
  24. (2001). DNA replication control through interaction of E2F-RB and the origin recognition complex.
  25. (2002). Dutta A
  26. (2000). Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts.
  27. (2004). Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression.
  28. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes.
  29. (1994). G1 phase progression: Cycling on cue.
  30. (1997). Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb.
  31. (2000). Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.
  32. (1970). Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species.
  33. (2000). Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha.
  34. (2002). Interdependent nuclear accumulation of budding yeast
  35. (1995). Matsukage A
  36. (2003). Metazoan origin selection: origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis.
  37. (1991). Modulation of retinoblastoma protein activity during the cell cycle.
  38. (2008). Novel DNA microarray system for analysis of nascent mRNAs.
  39. (1999). ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.
  40. (1995). Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor b1.
  41. (2007). Phosphorylation of Sld2 and Sld3 by cyclindependent kinases promotes DNA replication in budding yeast.
  42. (1993). Physical interaction of the retinoblastoma protein with human D cyclins.
  43. (1984). Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor.
  44. (1971). Products of RNA polymerases in HeLa cell nuclei.
  45. (1999). Ras enhances Myc protein stability.
  46. (1996). Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.
  47. (1992). Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.
  48. (1998). Retinoblastoma protein recruits histone deacetylase to repress transcription.
  49. (1997). Role of the Rb/E2F pathway in cell growth control.
  50. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
  51. (2001). Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle.
  52. (1974). The alpha-amanitin on RNA synthesis in Chinese hamster ovary cells.
  53. (1996). The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.
  54. (1976). The Inhibition by DRB (5,6 dichloro-1-beta-D-ribofuranosylbenzimidazole) of hnRNA and mRNA Production in HeLa Cells.
  55. (1996). The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif.
  56. (1997). The replication origin decision point is a mitogenindependent, 2-aminopurine-sensitive, G1-phase event that precedes restriction point control.
  57. (2004). The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation.
  58. (2003). Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells.
  59. (1995). Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription.
  60. (1995). Transforming growth factor beta and cell cycle regulation.
  61. (2000). Uninterrupted MCM2-7 function required for DNA replication fork progression.

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