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Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells

By Young-Sook Baek, Stefan Haas, Holger Hackstein, Gregor Bein, Maria Hernandez-Santana, Hans Lehrach, Sascha Sauer and Harald Seitz
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central
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    1. (2006). A: A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science
    2. (2005). A: Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.
    3. (2005). Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science
    4. (1999). Akira S: Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity
    5. (2000). AL: BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol
    6. (1999). Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science
    7. (2007). BL: The transcription factor MEF2C is required for craniofacial development. Dev Cell
    8. (2005). BR: Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. Cell
    9. (2000). Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity
    10. (1998). Celada A: Transcription factors that regulate monocyte/macrophage differentiation.
    11. (2007). Chawla S: MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length. Neurosci Lett
    12. (2002). Chromatin structure and gene regulation in the immune system. Annu Rev Immunol
    13. (2005). Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
    14. (2001). Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.
    15. (2007). EN: MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell
    16. (2000). EN: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature
    17. (1980). Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).
    18. (1976). Establishment and characterization of a human histiocytic lymphoma cell line (U-937).
    19. (2007). et al.: Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells. Blood
    20. (2002). Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages.
    21. (2007). gene expression at different stages of skeletal myogenesis. The Journal of biological chemistry
    22. (2007). Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature
    23. (1990). GW: Surface phenotype analysis of human monocyte to macrophage maturation.
    24. (2003). H: Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther
    25. (2005). HB: The U937 cell line induced to express CD14 protein by 1,25-dihydroxyvitamin D3 and be sensitive to endotoxin stimulation. Hepatobiliary Pancreat Dis Int
    26. (1996). Hirano T: A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.
    27. (2004). Interferon-alpha induction through Toll-like receptors involves a direct interaction of
    28. (2005). JL: Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling. P r o c N a t l A c a d S c i U S A
    29. (1992). Kehrl JH: A diverged homeobox gene is involved in the proliferation and lineage commitment of human hematopoietic progenitors and highly expressed in acute myelogenous leukemia. Blood
    30. (2007). L: p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev
    31. (2005). LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology
    32. (2006). LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression.
    33. (2006). MK: Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci USA
    34. (2005). MK: Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages.
    35. (2005). MK: Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol
    36. (2004). Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT).
    37. (2002). Olson EN: Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell
    38. (2007). Olson EN: Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation. Mol Cell Biol
    39. (1998). Olson EN: Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol
    40. (2005). Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis.
    41. (2008). Pickup JC: Innate immunity, insulin resistance and type 2 diabetes. Trends Endocrinol Metab
    42. (2007). Prime suspect: the TCF7L2 gene and type 2 diabetes risk.
    43. (2007). Rando OJ: Dynamics of replication-independent histone turnover in budding yeast. Science
    44. (2004). Reddy EP: Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation. Blood
    45. (2004). Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. Am J Physiol Lung Cell Mol Physiol
    46. (1995). Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol
    47. (2006). S: NF-kappaB and the immune response. Oncogene
    48. (2005). Shlomchik MJ: Immunobiology, the immune system in health and disease. Garland Science Publishing/New York;
    49. (2005). T: TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta.
    50. (2004). TA: Protein kinases C and D mediate agonistdependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol
    51. (2009). The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues. BMC evolutionary biology
    52. (2007). The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
    53. (2005). Tontonoz P: Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.
    54. (2006). Tontonoz P: Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol
    55. (1997). Ulevitch RJ: Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature
    56. (2002). Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics

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