Skip to main content
Article thumbnail
Location of Repository

Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans

By Yumie Rhee, Junho Lee, Ji Young Jung, Jung Eun Lee, So Young Park, Yoo Mee Kim, Sihoon Lee, Han Seok Choi, Se Hwa Kim and Sung-Kil Lim


To identify a proper T-score threshold for the diagnosis of osteoporosis in Koreans using quantitative ultrasonography (QUS), normative data from 240 females and 238 males (ages 20-29 yr) were newly generated. Then, the osteoporosis prevalence estimate for men and women over 50 yr of age was analyzed using previous World Health Organization (WHO) methods and heel QUS. T-scores were calculated from the normative data. There were definite negative correlations between age and all of the QUS parameters, such as speed of sound (SOS), broadband ultrasound attenuation (BUA), and estimated heel bone mineral density (BMD) (p<0.0001). After applying the recently determined prevalence of incident vertebral fracture in Koreans over 50 yr of age (11.6% and 9.1%, female vs male, respectively) to the diagnosis of osteoporosis by T-scores from heel BMD as measured by QUS, it was revealed that applicable T-scores for women and men were -2.25 and -1.85, respectively. These data suggest that simply using a T-score of -2.5, the classical WHO threshold for osteoporosis, underestimates the true prevalence when using peripheral QUS. Further prospective study of the power of QUS in predicting the absolute risk of fracture is needed

Topics: Original Article
Publisher: The Korean Academy of Medical Sciences
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1994). Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int
  2. (2006). Calcaneus ultrasound in males: normative data in the Croatian population (ECUM study).
  3. (2000). Can the WHO criteria for diagnosingosteoporosis be applied to calcaneal quantitative ultrasound? Osteoporos Int
  4. (1997). Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification. J Bone Miner Res
  5. (1985). Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev
  6. (1992). How many women have osteoporosis?
  7. (2001). Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA
  8. (1999). Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J Bone Miner Res
  9. (1994). Organization. Assessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis: report of a WHO study group.
  10. (1991). Pathway of ultrasound waves in the equine third metacarpal bone.
  11. (1993). Relation between body size and bone mineral density in elderly men and women.
  12. (1995). Relation of early menarche to high bone mineral density. Calcif Tissue Int
  13. (2007). Study of an osteoporosis management program in Korea. Management center for health promotion of Korea.
  14. (1984). The measurement of broadband ultrasonic attenuation in cancellous bone. Eng Med
  15. (1993). Ultrasound assessment of bone.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.