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Longitudinal neurocognitive outcome in an adolescent with Hurler-Scheie syndrome

By T David Elkin, Gail Megason, Anita Robinson, Hans-Georg O Bock, Gregory Schrimsher and Joseph Muenzer

Abstract

An adolescent with Hurler-Scheie syndrome is reported. This now 15 year-old-young woman was initially diagnosed at age 4. She was assessed for neurocognitive functioning at ages 5, 13, and 15 years. Results show a significant decline in intellectual functioning from the superior range to the average range from age 5 to age 13, and then no change from age 13 to age 15. The relationship between Hurler-Scheie syndrome, premorbid intellectual functioning, and cognitive–behavioral interventions are discussed in light of the longitudinal neurocognitive effects of this disease

Topics: Case Reports
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:2671818
Provided by: PubMed Central
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