Skip to main content
Article thumbnail
Location of Repository

Dietary essential fatty acids and gender-specific behavioral responses in cranially irradiated rats

By T David Elkin, Michael O Wollan, Stacy L Anderson, Robert Gaston, William Meyer, Bernard F Fuemmeler, Frank A Holloway and Rex E Martin

Abstract

Specific memory deficits, reduced intellectual processing speed, and a variety of social and behavioral problems have been implicated as long-term effects of cranial radiation therapy (CRT). These deficits are thought to be related to changes in brain cytology and structure associated with microvascular aberrations. N-3 fatty acids may serve as protectants in pediatric patients who receive CRT for brain tumors. Timed-pregnant rat dams were fed one of four diets that were identical in all respects, except for their essential fatty acid content. The dams were placed on these diets at the beginning of the third trimester of gestation and their pups remained on them throughout the study. The rats’ behavioral response as judged by acoustic startle response (ASR) and neurocognitive response (performance in a radial maze, RM) were evaluated in relation to diet, gender, and CRT. The following hypotheses were tested: (1) female rats will show greater CRT-induced neurocognitive and behavioral deficits; (2) dietary n-3 fatty acids will diminish CRT-induced neurocognitive and behavioral deficits; (3) gender-specific differences would be dampened by n-3 fatty acids in the diet. All three hypotheses were partially supported. These findings are discussed in light of the potential neuroprotective effects of n-3 fatty acids

Topics: Original Research
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:2671816
Provided by: PubMed Central

Suggested articles

Citations

  1. (1999). Acute lymphoblastic leuykemias and brain tumors.
  2. (1990). Docosahexaenoic acid is the preferred dietary n-3 acid for the development of the brain and retina. Pediatr Res,
  3. (1995). Docosahexaenoic acid status and developmental quotient of healthy term infants.
  4. (1995). Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice:the role of longchain polyunsaturated fatty acids. Pediatr Res,

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.