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Characterization of PR-10 genes from eight Betula species and detection of Bet v 1 isoforms in birch pollen

By Martijn F Schenk, Jan HG Cordewener, Antoine HP America, Wendy PC van't Westende, Marinus JM Smulders and Luud JWJ Gilissen
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

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  2. (2008). America AHP: Post alignment clustering procedure for comparative quantitative proteomics LC-MS Data. Proteomics
  3. (2005). AP: Concerted and birth-and-death evolution of multigene families. Annual Review of Genetics
  4. (2007). Assessing allergen levels in peach and nectarine cultivars. Ann Allergy Asthma Immunol
  5. (1996). Bean ribonuclease-like pathogenesis-related protein genes (Ypr10) display complex patterns of developmental, dark-induced and exogenousstimulus-dependent expression.
  6. (1998). Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, crossreact at the level of allergen-specific T helper cells.
  7. (2003). Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level.
  8. (1999). Concerted evolution: Molecular mechanism and biological implications.
  9. (1999). Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen. Molecular Immunology
  10. (2003). Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier.
  11. (1997). CS: Characterization of a lily tapetal transcript that shares sequence similarity with a class of intracellular pathogenesis-related (IPR) proteins. Plant Molecular Biology
  12. (2000). Detection and seasonal expression pattern of a pathogenesis-related protein (PR-10) in Douglas-fir (Pseudotsuga menziesii) tissues. Physiologia Plantarum
  13. (2003). DNA polymorphism analyses by the coalescent and other methods. Bioinformatics
  14. (1995). E, et al.: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid-chromatography, mass-spectrometry, and cDNA cloning.
  15. (1995). EAM: Influence of the pH of the extraction medium on the composition of birch (Betula verrucosa) pollen extracts. Allergy
  16. (1997). Ebner C: Isoforms of atopic allergens with reduced allergenicity but conserved T cell antigenicity: Possible use for specific immunotherapy. Int Arch Allergy Immunol
  17. (2004). Emanuelsson CS: Bet v 1 homologues in strawberry identified as IgE-binding proteins and presumptive allergens. Allergy
  18. (1997). Epitope analysis of birch pollen allergen in Japanese subjects.
  19. (2001). Esnault R: Molecular characterization of the incompatible interaction of Vitis vinifera leaves with Pseudomonas syringae pv. pisi: Expression of genes coding for stilbene synthase and class 10 PR protein.
  20. (1996). et al.: Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy.
  21. (1998). et al.: Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. Faseb Journal
  22. (2000). Evolution of gene families. Gene
  23. (2001). Expression of a Bet v 1 homologue gene encoding a PR 10 protein in birch roots: induction by auxin and localization of the transcripts by in situ hybridization.
  24. (1997). Genomic characterization of members of the Bet v 1 family: genes coding for allergens and pathogenesis-related proteins share intron positions. Gene
  25. (2005). Genomic cloning and linkage mapping of the Mal d 1 (PR10) gene family in apple (Malus domestica). Theoretical And Applied Genetics
  26. (2008). Gilissen LJWJ: Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity.
  27. (1999). H: New Bet v 1 isoforms including a naturally occurring truncated form of the protein derived from Austrian birch pollen. Molecular Immunology
  28. (2007). Hengel AJ: Proteomics-based approach to detect and identify major allergens in processed peanuts by capillary LC-Q-TOF (MS/MS). J Agric Food Chem
  29. (1989). IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy
  30. (1995). Isoallergens – significance in allergen exposure and response.
  31. (2005). Knulst AC, et al.: In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars.
  32. (2005). Localisation and distribution of the major allergens in apple fruits. Plant Science
  33. (2007). MAJS: Purification and characterization of natural Bet v 1 from birch pollen and related allergens from carrot and celery. Mol Nutr Food Res
  34. (1996). Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Analytical Chemistry
  35. (2000). MLD: The promoter of an apple Ypr10 gene, encoding the major allergen Mal d 1, is stress- and pathogeninducible. Plant Science
  36. (2000). Molecular and biochemical classification of plant-derived food allergens.
  37. (1997). Montagu M: Antagonistic effects of abscisic acid and jasmonates on salt stress-inducible transcripts in rice roots. Plant Cell
  38. (2008). Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy. J Allergy Clin Immunol
  39. (1995). O: cDNA cloning and characterization of three genes in the Bet v 1 gene family that encode pathogenesis-related proteins. Plant Cell and Environment
  40. (1993). PC: An introduction to betula: Its morphology, evolution, classification and distribution with a survey of recent work.
  41. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4 Sinauer Associates,
  42. (2004). Phylogenetic relationships of Betula species (Betulaceae) based on nuclear ADH and chloroplast matK sequences.
  43. (2003). Pollen from different olive tree cultivars contains varying amounts of the major allerge n ole e 1. International Archives of Allergy and Immunology
  44. (1999). Pollenrelated food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen.
  45. (2005). Quantitative proteomic analysis by accurate mass retention time pairs. Analytical Chemistry
  46. (1998). Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: A quantitative IgE inhibition study with sera from different populations.
  47. (2003). S: Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) and celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure.
  48. (1998). S: PR-10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula. Plant Cell and Environment
  49. (1998). Sensitization according to skin prick testings in atopic patients with asthma or rhinitis at 24 allergy clinica in Northern Europe and Asia. Allergology International
  50. (2006). Smulders MJM: Seven different genes encode a diverse mixture of isoforms of Bet v I, the major birch pollen allergen.
  51. (1999). Strien EA: The families of pathogenesisrelated proteins, their activities, and comparative analysis of PR-1 type proteins. Physiological and Molecular Plant Pathology
  52. (1989). The gene coding for the major birch pollen allergen BetvI, is highly homologous to a pea disease resistance response gene.
  53. (1997). The potential of Betv1 homologues, a nuclear multigene family, as phylogenetic markers in flowering plants. Mol Phylogenet Evol.
  54. (1998). Two members of the Bet v 1 gene family encoding birch pathogenesis-related proteins display different patterns of root expression and woundinducibility.
  55. (1999). Vapaavuori E: Expression of photosynthesis- and senescence-related genes during leaf development and senescence in silver birch (Betula pendula) seedlings. Physiologia Plantarum
  56. (2008). Vegetable proteomics: the detection of Ole e 1 isoallergens by peptide matching of MALDI MS/MS spectra of underivatized and dansylated glycopeptides. Journal of proteome research
  57. (1995). Vicente O: Expression of Bet v 1, the major birch pollen allergen, during anther development – An in situ hybridization study. Protoplasma

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