journal article
oaidoi:10.1016/0014-5793(86)80063-1

Sugar transport in Trypanosoma brucei: a suitable kinetic probe

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Publication date
1 January 1986
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Published by Elsevier B.V.
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    Abstract

    AbstractA transport assay has been developed for use in the investigation of 1-deoxy-D-glucose uptake in trypanosomes. 1-Deoxy-D-glucose has high affinity for the trypanosome sugar transport system (net influx Km = 4.03 ± 0.42 mM; V = 0.052 ± 0.005 mM·s−. D-Glucose oxidation is competitively inhibited by 1-deoxy-Dglucose. However, we show that 1-deoxy-D-glucose is not a substrate for metabolism and that the competition occurs because of interaction at the transport system. D-Glucose competitively inhibits 1-deoxy-D-glucose influx

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