Skip to main content
Article thumbnail
Location of Repository

Phosphodiesterase 5 Inhibition Improves β-Cell Function in Metabolic Syndrome

By Kevin D. Hill, Aaron W. Eckhauser, Annis Marney and Nancy J. Brown
Topics: Original Research
Publisher: American Diabetes Association
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (2002). ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO. Hypertension
    2. (2008). Beta cell mass in diabetes: a realistic therapeutic target? Diabetologia
    3. Chronic treatment with sildenafil improves energy balance and insulin action in high fat–fed conscious mice.
    4. Cross-talk between the insulin and angiotensin signaling systems.
    5. (1990). Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans.
    6. (2004). Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia
    7. Exogenous nitric oxide and endogenous glucose-stimulated-cell nitric oxide augment insulin release.
    8. FordES,GilesWH,DietzWH.Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.
    9. (1994). GreenIC.Theeffectofnitricoxidedonors on insulin secretion, cyclic GMP and cyclic AMP in rat islets of Langerhans and the insulin-secreting cell lines HIT-T15 and RINm5F. Mol Cell Endocrinol
    10. Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.
    11. (1995). LundquistI.Influenceofnitricoxidesynthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues.
    12. (1998). Nitric oxide does not initiate but potentiates glucose-induced insulin secretion in pancreatic beta-cells.
    13. Prevention of type 2 diabetes mellitus through inhibition of the reninangiotensin system.
    14. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes.
    15. Two distinct effects of cGMP on cytosolic Ca2 concentration of rat pancreatic beta-cells.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.