Skip to main content
Article thumbnail
Location of Repository

High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing

By Ke-Ping Xu, Yanfeng Li, Alexander V. Ljubimov and Fu-Shin X. Yu
Topics: Original Article
Publisher: American Diabetes Association
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1996). A simple organ culture model for assessing the effects of growth factors on corneal re-epithelialization. Exp Eye Res
  2. (1996). Acceleration of corneal wound healing in diabetic rats by the antioxidant trolox. Res Commun Mol Pathol Pharmacol
  3. AKT/PKB signaling: navigating downstream.
  4. ALDH3A1: a corneal crystallin with diverse functions.
  5. Altered epithelial-basement membrane interactions in diabetic corneas.
  6. an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat.
  7. (1995). An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci
  8. Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy.
  9. (2006). Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. Diabetes
  10. Blinking and superficial punctate keratopathy in patients with diabetes mellitus.
  11. (2005). Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species. Curr Hypertens Rep
  12. Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.
  13. Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing.
  14. (2001). Corneal advanced glycation end products increase in patients with proliferative diabetic retinopathy. Diabetes Care
  15. Corneal diabetic neuropathy: a confocal microscopy study.
  16. Corneal epithelial basement membrane changes in diabetes.
  17. Corneal epithelial changes in diabetic rats..
  18. (1995). Corneal epithelial fragility in diabetes mellitus.
  19. Corneal reepithelialization in galactosemic rats.
  20. (2007). Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes. Diabetes Care
  21. (2007). Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat. Invest Ophthalmol Vis Sci
  22. Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression.
  23. (2007). Deviated mechanism of wound healing in diabetic corneas..
  24. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.
  25. Diabetic embryopathy: studies using a rat embryo culture system and an animal model. Congenit Anom (Kyoto)
  26. (1981). Diabetic keratopathy.. Trans Am Ophthalmol Soc
  27. Diffuse punctate keratitis in a patient treated with cetuximab as monotherapy.
  28. (2009). Effect of EGF on the corneal wound healing of alloxan diabetic mice.
  29. Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications.
  30. Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes.
  31. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.
  32. (1991). Estrone modulates the EGF receptor in the liver of db/db mouse.
  33. (1997). Heterogeneous expression of transketolase ocular tissues. Curr Eye Res
  34. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.
  35. (1998). Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy.
  36. (2003). Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture. Exp Eye Res
  37. Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats.
  38. Is autologous serum a tonic for the ailing corneal epithelium?
  39. (2007). JW: High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 56:1559–1568,
  40. Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor.
  41. (2000). Matrix metalloproteinase activity is enhanced during corneal wound repair in high glucose condition. Curr Eye Res
  42. Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice.
  43. Non-enzymatic glycation in corneas from normal and diabetic donors and its effects on epithelial cell attachment in vitro.
  44. (1992). Ocular manifestations of diabetes mellitus.
  45. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase.
  46. Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.
  47. Practical management of patients with non-small-cell lung cancer treated with gefitinib.
  48. (1995). Prevention and treatment of the complications of diabetes mellitus.
  49. Prevention of diabetic keratopathy.
  50. Prolonged exposure to high glucose impaired cellular behavior of normal human corneal epithelial cells.
  51. (2003). Promotion of corneal epithelial wound healing in diabetic rats by the combination of a substance P-derived peptide (FGLM-NH2) and insulinlike growth factor-1. Diabetologia
  52. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.
  53. (2006). Reduced expression of laminin-5 in corneal epithelial cells under high glucose condition. Cornea
  54. (2002). Region-specific pathophysiological alterations occurring in calf lenses in vitro during hyperglycemia. Graefes Arch Clin Exp Ophthalmol
  55. response to oxidative stress.
  56. (1998). The effect of elevated extracellular glucose on migration, adhesion and proliferation of SV40 transformed human corneal epithelial cells. Curr Eye Res
  57. (2007). The epidermal growth factor receptor: from development to tumorigenesis. Differentiation
  58. The pathobiology of diabetic complications: a unifying mechanism..
  59. The role of corneal crystallins in the cellular defense mechanisms against oxidative stress.
  60. (1996). Transketolase is a major protein in the mouse cornea.
  61. (2009). Transmission electron microscopy and autofluorescence findings in the cornea of diabetic rats treated with aminoguanidine.
  62. Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study.
  63. Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus.
  64. (2004). Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells. Invest Ophthalmol Vis Sci

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.