journal articlereview
oaidoi:10.1016/j.cell.2010.04.014

Epigenetics Drives RAGs to Recombination Riches

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Publication date
30 April 2010
Publisher
Elsevier Inc.
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    Abstract

    V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages of lymphoid development

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