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Stimulation with Peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes

By Kolapo M Ajuwon, William Banz and Todd A Winters
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central
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    1. (2005). Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes.
    2. (2000). Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation
    3. (2006). Akira S: TLR signaling. Cell Death Differ
    4. (2005). Akira S: Toll-like receptors in innate immunity. Int Immunol
    5. (2001). CB: Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.
    6. (2003). CH: Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun-NH2-terminal kinase.
    7. (2003). Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue.
    8. (2006). Flier JS: TLR4 links innate immunity and fatty acid-induced insulin resistance.
    9. (2005). function and their ligands. Folia Biol (Praha)
    10. (2000). Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages.
    11. (2003). H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
    12. (2000). Haegeman G: Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem Pharmacol
    13. (2007). High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance. Biochem Biophys Res Commun
    14. (2007). Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Bio
    15. (2004). Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes.
    16. (2005). Ip YT: Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol
    17. (2002). Kadowaki T: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med
    18. (2003). Kadowaki T: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature
    19. (2007). McTernan PG: The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes.
    20. (2006). MK: Preadipocytes mediate lipopolysaccharideinduced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology
    21. (2007). MP: Innate immunity modulates adipokines in humans.
    22. (2007). Naaz A: Obesity, inflammation, and insulin resistance. Gastroenterology
    23. (2002). NB: Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA
    24. (2007). Olefsky JM: A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.
    25. (2005). Palmitate activates the NF-kappaB transcription factor and induces IL6 and TNF alpha expression in 3T3-L1 adipocytes.
    26. (2008). PE: Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology
    27. (2000). PE: The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes.
    28. (2007). Reifel-Miller A: Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. Endocrinology
    29. (2007). S: Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes.
    30. (2004). Spurlock ME: Adiponectin differentially regulates cytokines in porcine macrophages.
    31. (2004). T: Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
    32. (2003). Takeda K: Role of adapters in Toll-like receptor signalling. Biochem Soc Trans
    33. (2006). Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation.
    34. (2006). Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes.
    35. (2004). Wood IS: Adipokines: inflammation and the pleiotropic role of white adipose tissue.
    36. (2007). Yang PC: Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: the role of TLR2 and NOD2. Immunol Cell Biol

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