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Guillain-Barré syndrome following hepatitis E

By Jean Philippe Loly, Estelle Rikir, Maxime Seivert, Emile Legros, Pierre Defrance, Jacques Belaiche, Gustave Moonen and Jean Delwaide

Abstract

Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E

Topics: Case Report
Publisher: The WJG Press and Baishideng
OAI identifier: oai:pubmedcentral.nih.gov:2669950
Provided by: PubMed Central
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