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An Exploratory Study on the Development of an Animal Model of Acute Pancreatitis Following Nicotine Exposure

By P Chowdhury


Cigarette smoking is known to be a major risk factor for pancreatic cancer and pancreatitis is believed to be a predisposed condition for pancreatic cancer. As of this date, there is no established experimental animal model to conduct detailed studies on these two deadly diseases. Our aim is to establish a rodent model by which we can systematically study the pathogenesis of pancreatitis and pancreatic cancer

Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1980). A possible metabolic basis for the control of body weight.
  2. (1976). A rapid and sensitive method for determination of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem
  3. (1978). Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini.
  4. (1975). Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine with a choline-deficient diet.
  5. (1985). Analysis of radioligand binding experiments: A collection of computer programs for the IBM PC.
  6. (1985). Caerulein induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology
  7. (1988). Characterization of cholecystokinin receptors on rat pancreatic membranes. Endocrinology
  8. (1999). Cigarette Smoking.
  9. (1991). Clinical application 216 Chowdhury P of ras gene mutation for diagnosis of pancreatic adenocarcinoma. Gastroenterology
  10. Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian Casuistic. J Pancreas 2002; 3:144-151. Development of an Animal Model of Pancreatitis Following Nicotine Exposure 217
  11. (1993). Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer res
  12. (1988). Effects of L-364,718 a new CCK antagonist on amylase secretion in isolated rat pancreatic acini. Pancreas
  13. (1998). Genetic influences on smoking: candidate genes. Environ Health Perspect
  14. (1986). Influence of obstructive jaundice on pancreatic growth and on basal plasma levels of cholecystokinin and gastrin in rats.
  15. (1992). Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology
  16. (1980). Ligand: A versatile computerized approach for characterization of ligandbinding systems.
  17. (1988). Most human carcinomas of the exocrine pancreas contain mutant K-ras genes. Cell
  18. (1990). Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology
  19. (2002). Pathophysiological effects of nicotine on the pancreas: an update. Exp Biol Med
  20. (1998). Pharmacogenetics and ethnoracial differences in smoking. JAMA
  21. (1980). Preparation and application of procion yellow starch for amylase assay. Clin Chim Acta
  22. (1992). protocols: A guide to methods and applications. Cetus Corporation,
  23. (1986). Role of cholecystokinin and opioid in control of food intake. Physiol Rev
  24. (1991). Smoking attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States?
  25. (1996). Society: Facts and Figures.
  26. (1959). Standard Methods of Clinical Chemistry, The Determination of Glucose by
  27. (1979). Stereological Methods. In Practical Methods for Biological Morphometry.
  28. (1984). Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell; early morphological alterations during development of experimental pancreatitis.
  29. (1983). The role of smoking in regulation of energy balance.
  30. (1989). Weight loss and circulating GI peptides in rats exposed chronically to nicotine.

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