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An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene

By Sreeram V Ramagopalan, Roisin McMahon, David A Dyment, A Dessa Sadovnick, George C Ebers and Knut M Wittkowski
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2008). and Ebers GC: Genes for multiple sclerosis. Lancet
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  4. (2005). et al: A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet
  5. (2007). et al: Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
  6. (2008). Greiner E and Dessa Sadovnick A, et al: Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet
  7. (2007). Mirel DB and Ivinson AJ, et al: Risk alleles for multiple sclerosis identified by a genomewide study.
  8. (2000). Multiple sclerosis.
  9. (2005). S a d o v n i c kA D ,R i s c hNa n dE b e r sG C :Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet
  10. (2007). Sadovnick AD and Ebers GC: Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium. Hum Mol Genet
  11. (2004). The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules. Nat Immunol
  12. (1995). The multiple sclerosisand narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele. Tissue Antigens

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