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Quality of life measurement in cancer patients receiving palliative radiotherapy for symptomatic lung cancer: a literature review

By N. Salvo, S. Hadi, J. Napolskikh, P. Goh, E. Sinclair and E. Chow

Abstract

Approximately 27% of North American cancer deaths are attributable to cancer of the lung. Many lung cancers are found at an advanced stage, rendering the tumours inoperable and the patients palliative. Common symptoms associated with palliative lung cancer include cough, hemoptysis, and dyspnea, all of which can significantly debilitate and diminish quality of life (qol). In studies of the effects of cancer therapies, the frequent evaluative endpoints are survival and local control; however, it is imperative that clinical trials with palliative patients also have a qol focus when a cure is unattainable. We conducted a literature review to investigate the use of qol instrument tools in trials studying qol or symptom palliation of primary lung cancer or lung metastases through the use of radiotherapy. We identified forty-three studies: nineteen used a qol tool, and twenty-four examined symptom palliation without the use of a qol instrument. The European Organization for Research and Treatment of Cancer (eortc) qlq-C30 survey was the most commonly used qol questionnaire (in thirteen of twenty trials). Of those thirteen studies, eight also incorporated the lung-specific qol survey eortc qlq-LC13 (or the eortc qlq-LC17). A second lung-specific survey, the Functional Assessment of Cancer Therapy–Lung (fact-L) was used in only two of the twenty trials. In total, only ten of forty-three trials (23%) used a lung-specific qol tool, suggesting that qol was of low priority as an endpoint and that measures created for lung cancer patients are underused. We encourage investigators in future trials to include specific qol instruments such as the eortc qlq-LC13 or the fact-L for studies in palliative thoracic radiotherapy because those instruments provide a measure of qol specific to patients with lung cancer or lung metastases

Topics: Radiation Oncology
Publisher: Multimed Inc.
OAI identifier: oai:pubmedcentral.nih.gov:2669235
Provided by: PubMed Central
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    Citations

    1. A palliative accelerated irradiation regimen for advanced non-small-cell lung cancer vs. conventionally fractionated 60 Gy: results of a randomized equivalence study.
    2. (1997). A phase iii study of radiotherapy with and without continuous-infusion fluorouracil as palliation for non-small-cell lung cancer.
    3. A prospective, randomised study to compare two palliative radiotherapy schedules for non-small-cell lung cancer (n s c l c ).
    4. (1988). A randomized study on palliative radiation therapy for inoperable non small cell carcinoma of the lung.
    5. (1997). A retrospective quality of life analysis using the Lung Cancer Symptom Scale in patients treated with palliative radiotherapy for advanced nonsmall cell lung cancer.
    6. A study of acute side-effects related to palliative radiotherapy treatment of lung cancer.
    7. A systematic overview of radiation therapy effects in non-small cell lung cancer.
    8. (1988). An evaluation of the palliative role of radiotherapy in inoperable carcinoma of the bronchus. Clin Radiol
    9. Assessing fatigue and self-care strategies in patients receiving radiotherapy for non-small cell lung cancer.
    10. (1989). Assessing the quality of life of cancer patients: practical issues in study implementation.
    11. (2005). Do elderly people with lung cancer benefit from palliative radiotherapy? Lung Cancer
    12. (2007). Endobronchial brachytherapy for symptom palliation in non-small cell lung cancer—analysis of symptom response, endoscopic improvement and quality of life. Lung Cancer
    13. (2003). External beam radiotherapy in bone metastatic prostate cancer: impact on patients’ pain relief and quality of life. Oncol Rep
    14. (2001). External irradiation versus external irradiation plus endobronchial brachytherapy in inoperable non-small cell lung cancer: a prospective randomized study. Radiother Oncol
    15. (1999). Hypofractionated radiation therapy for inoperable advanced stage non-small cell lung cancer.
    16. (1997). Immediate side effects of large fraction radiotherapy.
    17. (1998). Inoperable non-small cell lung cancer: palliative radiotherapy with two weekly fractions.
    18. Kaasa S on behalf of the Norwegian Lung Cancer Study Group. Palliative thoracic radiotherapy in locally advanced non-small cell lung cancer: can quality-of-life assessments help in selection of patients for short- or long-course radiotherapy?
    19. (1981). Measuring the quality of life of cancer patients: a concise q l -index for use by physicians.
    20. Mehta MP on behalf of the Eastern Cooperative Oncology Group. Quality of life assessment in advanced non-small-cell lung cancer patients undergoing an accelerated radiotherapy regimen: report of ECOG study 4593.
    21. on behalf of the Clinical Trials Group of the National Cancer Institute of Canada. Randomized phase iii trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer (n c i c c t g s c.15).
    22. (2005). on behalf of the Norwegian Lung Cancer Study Group. Immediate or delayed radiotherapy in advanced non-small cell lung cancer (n s c l c )? Data from a prospective randomised study. Radiother Oncol
    23. Optimization of dose and fractionation of endobronchial brachytherapy with or without external radiation in the palliative management of non-small cell lung cancer: a prospective randomized study.
    24. (1991). Palliation and life quality in lung cancer; how good are clinicians at judging treatment outcome?
    25. (1995). Palliative radiation for stage 3 non-small cell lung cancer—a prospective study of two moderately high dose regimens. Lung Cancer
    26. (1985). Palliative radiotherapy for inoperable carcinoma of the lung: final report of a r t o g multi-institutional trial.
    27. Palliative radiotherapy for lung cancer: two versus five fractions.
    28. Palliative radiotherapy for synchronous bilateral lung cancers.
    29. Phase ii study: integrated palliative care in newly diagnosed advanced non-smallcell lung cancer patients.
    30. (2000). Pretreatment quality of life of inoperable non-small cell lung cancer patients referred for primary radiotherapy. Acta Oncol
    31. Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study.
    32. Quality of life of lung cancer patients in a randomized clinical trial evaluated by a psychosocial well-being questionnaire. Acta Oncol 1988;27:335–42.
    33. (1995). Quality-of-life and cost-effectiveness assessment in lung cancer. Curr Opin Oncol
    34. (2004). Quality-of-life trials in lung cancer: past achievements and future challenges. Hematol Oncol Clin North Am
    35. (1997). Radiotherapy in the elderly with lung carcinoma: the experience of the Italian “Geriatric Radiation Oncology Group.” Rays
    36. (1996). Randomized trial of palliative two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung
    37. (1997). Relationships between biochemical and symptomatic response in a double-blind randomised trial of pamidronate for metastatic bone disease. Ann Oncol
    38. (2004). Research Associates. Lung Cancer Symptom Scale. Charlottesville, VA: Quality of Life Research Associates;
    39. Response of global quality of life to highdose palliative radiotherapy for non-small-cell lung cancer.
    40. Results of the Dutch National study of the palliative effect of irradiation using two different treatment schemes for non-small-cell lung cancer.
    41. Short-course palliative radiotherapy for airway stenosis in non-small cell lung cancer.
    42. (2007). Society and the National Cancer Institute of Canada. Canadian Cancer Statistics
    43. Symptom control and quality of life in people with lung cancer: a randomised trial of two palliative radiotherapy fractionation schedules.
    44. The European Organization for Research and Treatment of Cancer core quality of life questionnaire (q l q -C30 version 3.0 Turkish) in cancer patients receiving palliative radiotherapy.
    45. The impact of symptoms, coping capacity, and social support on quality of life experience over time in patients with lung cancer.
    46. The role of palliative radiotherapy in locally advanced nonsmall cell lung cancer.
    47. The role of palliative thoracic radiotherapy in non-small cell lung cancer.
    48. (1977). The role of radiotherapy in treatment of inoperable lung cancer.
    49. Ung YC on behalf of the Lung Cancer Disease Site Group of Cancer Care Ontario’s Program in Evidence-Based Care. Management of unresected stage III non-small cell lung cancer: a systematic review.
    50. (1992). Working Party. A Medical Research Council (m r c ) randomised trial of palliative radiotherapy with two fractions or a single fraction in patients with inoperable non-small-cell lung cancer (n s c l c ) and poor performance status.

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