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Perturbation of Interaction Networks for Application to Cancer Therapy

By Adrian P. Quayle, Asim S. Siddiqui and Steven J. M. Jones

Abstract

We present a computational approach for studying the effect of potential drug combinations on the protein networks associated with tumor cells. The majority of therapeutics are designed to target single proteins, yet most diseased states are characterized by a combination of many interacting genes and proteins. Using the topology of protein-protein interaction networks, our methods can explicitly model the possible synergistic effect of targeting multiple proteins using drug combinations in different cancer types

Topics: Systems Biology Special Issue
Publisher: Libertas Academica
OAI identifier: oai:pubmedcentral.nih.gov:2666951
Provided by: PubMed Central
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