Skip to main content
Article thumbnail
Location of Repository

Gastrointestinal Stromal Tumors (GIST) and Their Management

By Robert G. Maki

Abstract

Gastrointestinal stromal tumor (GIST) is the most common form of sarcoma and can vary in size and clinical outcome from an incidental finding at the time of surgery to life-threatening metastatic disease. Surgery is the standard of care for primary disease, and the oral drug imatinib is the standard of care for metastatic disease. Sunitinib was approved in the United States in early 2006 for GIST refractory to imatinib. The pathology of GIST, surgical options for primary and metastatic disease, and findings leading to the use of imatinib and sunitinib for GIST are reviewed in this manuscript, with attention to the mutation statuses of c-kit and PDGF receptor that lead to imatinib sensitivity or resistance

Topics: Feature Article
Publisher: International Society of Gastrointestinal Oncology
OAI identifier: oai:pubmedcentral.nih.gov:2666831
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.