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Biological Co-Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility

By Steven M Tommasini, Philip Nasser, Bin Hu and Karl J Jepsen


A path analysis was conducted to determine whether functional interactions exist among morphological, compositional, and microstructural traits for young adult human tibias. Data provided evidence that bone traits are co-adapted during ontogeny so that the sets of traits together satisfy physiological loading demands. However, certain sets of traits are expected to perform poorly under extreme load conditions

Topics: Original Articles
Publisher: Amer Soc Bone & Mineral Res.
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Provided by: PubMed Central
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