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Smooth Pursuit–Related Information Processing in Frontal Eye Field Neurons that Project to the NRTP

By Seiji Ono and Michael J. Mustari


The cortical pursuit system begins the process of transforming visual signals into commands for smooth pursuit (SP) eye movements. The frontal eye field (FEF), located in the fundus of arcuate sulcus, is known to play a role in SP and gaze pursuit movements. This role is supported, at least in part, by FEF projections to the rostral nucleus reticularis tegmenti pontis (rNRTP), which in turn projects heavily to the cerebellar vermis. However, the functional characteristics of SP-related FEF neurons that project to rNRTP have never been described. Therefore, we used microelectrical stimulation (ES) to deliver single pulses (50–200 μA, 200-μs duration) in rNRTP to antidromically activate FEF neurons. We estimated the eye or retinal error motion sensitivity (position, velocity, and acceleration) of FEF neurons during SP using multiple linear regression modeling. FEF neurons that projected to rNRTP were most sensitive to eye acceleration. In contrast, FEF neurons not activated following ES of rNRTP were often most sensitive to eye velocity. In similar modeling studies, we found that rNRTP neurons were also biased toward eye acceleration. Therefore, our results suggest that neurons in the FEF–rNRTP pathway carry signals that could play a primary role in initiation of SP

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    1. (1966). A method for measuring horizontal and vertical eye movement chronically in the monkey.
    2. (2008). A theory of the dual pathways for smooth pursuit based on dynamic gain control.
    3. (2000). Cerebellar flocculus and ventral paraflocculus Purkinje cell activity during predictive and visually driven pursuit in monkey.
    4. (1990). Cerebral hemispheric localization of smooth pursuit asymmetry.
    5. (2007). Contribution of the frontal eye field to gaze shifts in the head-unrestrained monkey: effects of microstimulation.
    6. (2001). Cortical and subcortical afferents to the nucleus reticularis tegmenti pontis and basal pontine nuclei in the macaque monkey. Vis Neurosci.
    7. (2002). Cortical projections to the nucleus of the optic tract and dorsal terminal nucleus and to the dorsolateral pontine nucleus in macaques: a dual retrograde tracing study.
    8. (2006). Cortico-cortical networks and corticosubcortical loops for the higher control of eye movements. Prog Brain Res.
    9. (1980). Corticopontine visual projections in macaque monkeys.
    10. (1996). Craniotopic defects of smooth pursuit and saccadic eye movement.
    11. (1988). Deficits in smooth-pursuit eye movements after muscimol inactivation within the primate’s frontal eye field.
    12. (1985). Deficits in visual motion processing following ibotenic acid lesions of the middle temporal visual area of the macaque monkey.
    13. (1986). Different patterns of corticopontine projections from separate cortical fields within the inferior parietal lobule and dorsal prelunate gyrus of the macaque. Exp Brain Res.
    14. (2007). Differential attentiondependent response modulation across cell classes in macaque visual area V4.
    15. (1987). Directional pursuit deficits following lesions of the foveal representation within the superior temporal sulcus of the macaque monkey.
    16. (2005). Discharge characteristics of pursuit neurons in MST during vergence eye movements.
    17. (2000). Effects of lesions of the oculomotor cerebellar vermis on eye movements in primate: smooth pursuit.
    18. (1977). Efferent connections of cortical, area 8 (frontal eye field) in Macaca fascicularis. A reinvestigation using the autoradiographic technique.
    19. (2002). Enhancement of multiple components of pursuit eye movement by microstimulation in the arcuate frontal pursuit area in monkeys.
    20. (2006). Extraretinal signals in MSTd neurons related to volitional smooth pursuit.
    21. (2003). Frontal cortical control of smooth-pursuit.
    22. (1986). Frontal eye field as defined by intracortical microstimulation in squirrel monkeys, owl monkeys, and macaque monkeys: I. Subcortical connections.
    23. (1991). Frontal eye field lesions impair predictive and visually-guided pursuit eye movements. Exp Brain Res.
    24. (1987). Frontal eye field lesions in monkeys disrupt visual pursuit. Exp Brain Res.
    25. (1996). Functionally defined smooth and saccadic eye movement subregions in the frontal eye field of Cebus monkeys.
    26. (1982). Further observations on the cerebellar projections from the pontine nuclei and the nucleus reticularis tegmenti pontis in the rhesus monkey.
    27. (2004). Gaze-related response properties of DLPN and NRTP neurons in the rhesus macaque.
    28. (2001). Gazestabilizing deficits and latent nystagmus in monkeys with early-onset visual deprivation: role of the pretectal not.
    29. (1991). Generation of smooth-pursuit eye movements: neuronal mechanisms and pathways. Neurosci Res.
    30. (1980). Implantation of magnetic search coils for measurement of eye position: an improved method. Vision Res.
    31. (2001). Information processing by parafoveal cells in the primate nucleus of the optic tract. Exp Brain Res.
    32. (1993). Inverse-dynamics model eye movement control by Purkinje cells in the cerebellum.
    33. (2007). Involvement of the cerebellar dorsal vermis in vergence eye movements in monkeys.
    34. (1993). Lesions of the frontal eye field impair pursuit eye movements, but preserve the predictions driving them. Behav Brain Res.
    35. (1994). Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field.
    36. (1988). Neuronal activity in the dorsolateral pontine nucleus of the alert monkey modulated by visual stimuli and eye movements. Exp Brain Res.
    37. (1998). Neuronal responses related to smooth pursuit eye movements in the periarcuate cortical area of monkeys.
    38. (2004). On the role of frontal eye field in guiding attention and saccades. Vision Res.
    39. (1985). Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements.
    40. (1990). Primate supplementary eye field: I. Comparative aspects of mesencephalic and pontine connections.
    41. (1987). Primer of bio-statistics. 4th ed.
    42. (1999). Quantitative analysis of abducens neuron discharge dynamics during saccadic and slow eye movements.
    43. (2004). Recasting the smooth pursuit eye movement system.
    44. (2001). Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortex.
    45. (1988). Relation of cortical areas MT and MST to pursuit eye movements. II. Differentiation of retinal from extraretinal inputs.
    46. (1988). Relation of cortical areas MT and MST to pursuit eye movements. III. Interaction with full-field visual stimulation.
    47. (1988). Response properties of dorsolateral pontine units during smooth pursuit in the rhesus macaque.
    48. (2003). Role of the dorsolateral pontine nucleus in short-term adaptation of the horizontal vestibuloocular reflex.
    49. (2000). Role of the pretectal nucleus of the optic tract in short-latency ocular following responses in monkeys. Exp Brain Res.
    50. (2002). Sensory-to-motor processing of the ocular-following response. Neurosci Res.
    51. (1993). Smooth eye movements elicited by microstimulation in the primate frontal eye field.
    52. (1988). Smooth-pursuit eye movement deficits with chemical lesions in the dorsolateral pontine nucleus of the monkey.
    53. (1991). Smooth-pursuit eye movement representation in the primate frontal eye field. Cereb Cortex.
    54. (2003). Smooth-pursuit eye-movementrelated neuronal activity in macaque nucleus reticularis tegmenti pontis.
    55. (1999). Smooth-pursuit eyemovement deficits with chemical lesions in macaque nucleus reticularis tegmenti pontis.
    56. (1987). Temporal encoding of two-dimensional patterns by single units in primate inferior temporal cortex. I. Response characteristics.
    57. (1998). Temporal firing patterns of Purkinje cells in the cerebellar ventral paraflocculus during ocular following responses in monkeys. I. Simple spikes.
    58. (2008). The basal ganglia: an overview of circuits and function. Neurosci Biobehav Rev.
    59. (2007). The contribution of the human FEF and SEF to smooth pursuit initiation. Cereb Cortex.
    60. (1980). The cortical projection to the nucleus reticularis tegmenti pontis in the rhesus monkey. Exp Brain Res.
    61. (2006). The neurology of eye movements. 4th ed.
    62. (2006). The oculomotor role of the pontine nuclei and the nucleus reticularis tegmenti pontis. Prog Brain Res.
    63. (1961). The relationship between saccadic and smooth tracking eye movements.
    64. (1990). Visual motion response properties of neurons in dorsolateral pontine nucleus of alert monkey.
    65. (1994). Visual pontocerebellar projections in the macaque.
    66. (1987). Visual processing in monkey extrastriate cortex. Annu Rev Neurosci.
    67. (1984). Visual signals in the dorsolateral pontine nucleus of the alert monkey: their relationship to smooth-pursuit eye movements. Exp Brain Res.

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