Skip to main content
Article thumbnail
Location of Repository

Non Heart-Beating Donors in England

By Eleazar Chaib

Abstract

When transplantation started all organs were retrieved from patients immediately after cardio-respiratory arrest, i.e. from non-heart-beating donors. After the recognition that death resulted from irreversible damage to the brainstem, organ retrieval rapidly switched to patients certified dead after brainstem testing. These heart-beating-donors have become the principal source of organs for transplantation for the last 30 years. The number of heart-beating-donors are declining and this is likely to continue, therefore cadaveric organs from non-heart-beating donor offers a large potential of resources for organ transplantation. The aim of this study is to examine clinical outcomes of non-heart-beating donors in the past 10 years in the UK as an way of decreasing pressure in the huge waiting list for organs transplantation

Topics: Review
Publisher: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
OAI identifier: oai:pubmedcentral.nih.gov:2664192
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. A case-control comparison of the results of renal transplantation from heart-beating and non-heart-beating donors.
    2. A comparison of the results of renal transplantation from non-heart-beating, conventional cadaveric, and living donors.
    3. A definition of irreversible coma. Report of the ad hoc committee of the Harvard Medical School to examine the definition of brain death.
    4. (1998). A good alternative to reduce the kidney shortage – kidneys from non-heart-beating donors.
    5. A report on the activity and clinical outcomes of renal non-heart-beating donor transplantation in the United Kingdom. Clin Transplantation.
    6. Activation of mitochondrial apoptotic pathways in human renal allografts after ischemia reperfusion injury.
    7. Advantage of cold storage over machine perfusion for preservation of cadaver kidneys.
    8. (1999). Amelioration of lung reperfusion injury by L- and E-selectin blockade. Eur J Cardiothor Surg.
    9. (1997). Are kidneys from non-heart-beating donors second class organs ? Transpl
    10. Assessment of cadaveric kidneys for transplantation.
    11. Canine renal preservation following hypothermic perfusion and subsequent function.
    12. (1995). Categories of non-heartbeating donors. Transpl
    13. (1988). Comparative study of the use of systolic and asystolic kidney donors between
    14. (1984). Comparison of cadaver kidney preservation methods in Eurotransplant. Transpl Proc
    15. Comparison of renal allograft fibrosis after transplantation from heart-beating and non-heart-beating donors.
    16. (1997). Comparison of the results of renal transplants from conventional and non-heart-beating cadaveric donors. Transpl
    17. Death rate trends for RTAs and CVAs.
    18. (1996). Delayed function reduces renal allograft survival independent of acute rejection. Nephrol Dial Transpl.
    19. Delayed graft function after renal transplantation.
    20. (1998). Delayed graft function does not reduce the survival of renal transplant allografts.
    21. (1996). Delayed graft function in the absence of rejection has no long-term impact. A study of cadaver kidneys recipients with good graft function at 1 year after transplantation.
    22. Diabetic donors as a source of non-heart-beating renal transplants. Transpl
    23. (1995). Early prognosisof 263 renal allografts harvested from non-heart-beating cadavers using an in situ cooling technique. Transpl Proc.
    24. Early results of anon-heratbeating donor (NHBD) programme with machine perfusion.
    25. (1997). Effect of machine perfusion preservation on delayed graft function in nonheart-beating donor kidneys-early results. Transpl Int.
    26. Effect of perioperative infusion of antioxidants on neutrophil activation during liver transplantation in humans. Transpl
    27. Effect of prolonged delayes graft function on long-term graft outcome in cadaveric kidney transplantation.
    28. (1994). Effectiveness of machine perfusion preservation as a viability determination method for kidneys procured from non-heart-beating donors. Transpl Proc.
    29. (1994). Estado atual do “split-liver” como opção técnica para o transplante de fígado. Revisão da literatura. Rev Hosp Clin Fac Med
    30. (1995). Estudo do sistema venoso hepático e sua aplicação na técnica de transplante de fígado chamada “ split-liver”. Rev Hosp Clin Fac Med
    31. (1999). Evaluation of ischemic injury during liver procurement from non-heart-beating donors. Eur Surg Res.
    32. Excellent longterm graft survival with kidneys from the uncontrolled non-heartbeating donor. Transpl
    33. (1995). Experience with liver and kidney allografts from non-heart-beating donors. Transplantation.
    34. (1996). Factors affecting graft function in cadaveric renal transplantation from non-heart-beating donors using a double balloon catheter. Transpl Proc.
    35. (1997). Factors influencing short and longterm survival of kidneys transplanted from non-heart-beating donors. Transpl Proc.
    36. Gama-Rodrigues J.The main hepatic anatomic variations for the purpose of split-liver transplantation.
    37. Glutathione S transferase as predictor of functional outcome in transplantation of machine preserved non-heartbeating donor kidneys.
    38. Glutathione transferase in the urine: a marker for post-transplant tubular lesions.
    39. Graft function after kidney transplantation from non-heart-beating donors according toaastricht category.
    40. Hepatic artery system variations correlated to split-liver surgery: anatomic study in cadavers.
    41. How to improve the quality of kidneys from non-heart-beating donors: a randomized controlled trial of thrombolysis in non-heartbeating donors.
    42. (1975). In situ preservation of cadáver kidneys for transplantation: laboratory observations and clinical application. Ann Surg.
    43. Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation.
    44. (1991). Ischaemic injury induces altered MHC, gene expression in kidney by an interferon-gamma dependent pathway. Transpl Proc.
    45. Ischemia-reperfusion injury in cadaveric nonheart beating, cadaveric heart beating and live donor renal transplants.
    46. (2004). Ischemiareperfusioninjury of the intestine and protective strategies against injury. Dig Dis Sci.
    47. Kidney retrieval from asystolic donors using an intra-aortic balloon catheter.
    48. (1994). Kidney retrieval from asystolic donors: a valuable and viable source of additional organs.
    49. (1996). Kidney transplantation from asystolic donors.
    50. Kidney trasplantation from donors without a heartbeat.
    51. (1975). Letter machine-perfused cadaver kidneys Lancet.
    52. Liver transplantation from controlled non-heart-beating donors: An increased incidence of biliary complications.
    53. Liver transplantation from controlled non-heart-beating donors.
    54. Liver Transplantation fron Non-Heart-Beating Donors: Current status and future prospects. Liver Transplantation.
    55. Liver transplantation: waiting list dynamics in the state of Sao Paulo,
    56. Long-term renal function in kidneys from non-heart-beating donors: a single-center experience. Transplant
    57. Long-term renal function in kidneys from nonheart-beating donors: a single-center experience.
    58. Long-term renal function in on non-heart-beating donor kidney transplantation: a single centre experience.
    59. Machine perfusion and viability assessment of Non-Heart-Beating Donor kidney – A single centre result. Transpl
    60. Moral principles of kidney donation in Japan. Transpl
    61. (2004). More transplants, New Lives.
    62. National impact of pulsatile perfusion on cadaveric kidney transplantation.
    63. (1996). New profile of cadaveric donors: what are the kidney donor limits ? Transpl Proc.
    64. Nicholson ML – Non-heart-beating donors for renal transplantation.
    65. (1995). Non heart-beating donors: Methods and techniques. Transpl
    66. Non-Heart beating Donor kidneys with delayed graft function have a superior graft survival compared with conventional heart-beating donor kidneys that developed delayed graft function.
    67. (1996). Non-heart-beating donor program contributes 40% of kidneys for transplantation.
    68. Non-heart-beating donors: renewed source of organs for renal transplantation during the twenty-first century.
    69. (1995). Non-heart-beating donors: The Leicester experience. Transpl
    70. (1999). Non-heartbeating kidney donors. Clin Transpl.
    71. (2003). Nonheart-beating kidney donation: current practice and future developments. Kidney Int.
    72. (1994). Nonheartbeating donors:the Maastricht experience. Clin Transpl.
    73. Outcome of renal allografts from non-heart-beating donors with delayed graft function.
    74. Outcome of transplantation of non-heart-beating donors kidneys.
    75. Outcome of transplantation of non-heartbeating kidneys.
    76. Outcome of transplantation using kidneys from controlled (Maastrich category 3) non-heart-beating donors. Clin Transplantation.
    77. (1995). Post-transplant long-term outcome of kidneys obtained from asystolic donors maintained under extracorporeal cardiopulmonary bypass. Transpl
    78. (1997). Predictors of graft outcome in warm ischemically damaged organs. Transpl Proc.
    79. (1988). preservation, and transport of cadaver kidneys. Surg Clin North Am.
    80. Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides. Transpl
    81. Preventive effectof inhalet nitric oxide and pentoxifylline on ischemia/perfusion injury after lung transplantation.
    82. (1996). PRF – The relative influence of delayed graft function and acute rejection on renal transplant survival. Transpl Int.
    83. (1995). Principais variações do sistema biliar extra-hepatico e sua aplicação na técnica de transplante de fígado chamada “split-liver”. Rev Hosp Clin Fac Med
    84. (1997). Procurement and transplantation of kidneys from non-heart-beating donors – an overview. Dig Surg.
    85. (1991). Procurement of kidney Grafts from non-heart-beating donors. Transpl
    86. (1998). Prolonged warm ischemia affects long-term prognosis of kidney transplant allografts from non-heartbeating donors. Transpl Proc.
    87. Protective strategies against ischemic injury of the liver.
    88. Pulsatile kidney perfusion and evaluation: use of high risk kidney donors to expand the donor pool. Transpl
    89. Randomized clinical trial of daclizumab induction and delayed introduction of tracolimus recipients of non-heart-beating kidney transplants.
    90. (1988). relaxing the death standard for organ donation in paediatric situations,
    91. Renal graft function after prolonged agonal time in non-heartbeating donors.
    92. (1993). Renal harvesting after in situ cooling by intra-aortic double balloon catheter. Transpl Proc.
    93. Renal transplantation from non-heart-beating donors: opportunities and challenges. Transpl Rev.
    94. Renal transplants from category III non-heart-beating donors with evidence of pre-arrest acute renal failure. Transpl
    95. (2004). Renal transplants from non-heart-beating paracetamol overdose donors. Clin Transplantation.
    96. (1999). Role of cytokines and cytokineproducing cells in reperfusion injury to the liver. Semin Liver Dis.
    97. (1998). Role of machine perfusion preservation in kidney transplantation from non-heart-beating donors. Clin Transpl.
    98. (1995). Round table discussion on nonheart-beating donors. Transpl
    99. (1996). Royal Colleges and their Faculties in the United Kingdom. Diagnosis of brain stem death.
    100. Sanni A et al. Dual renal transplantation from kidneys from marginal nonheart-beating donors. Transpl
    101. Segmental liver transplantation from non-heartbeating donors- An early experience with implications for the future.
    102. (1996). Storage by continuous hypothermic perfusion for kidney harvested from hemodynamically unstable donors. Transpl Proc.
    103. (1997). Strategy for eliminating the kidney shortage. Clin Transpl.
    104. Survival following liver transplantation from non-heart-beating donors. Ann Surg.
    105. (1998). The British Transplantation Society. Towards standards for organ and tissue transplantation in the United Kingdom.
    106. The effect of ischaemic injury on kidneys preserved for 24 h before transplantation.
    107. (1998). The fate of 359 renal allografts harvested from non-heart-beating cadáver donors at a single center. In:
    108. (1997). The non-heart beating donor Br Med Bull.
    109. The troble with kidneys derived from non-heart-beating donor: a single center 10-year experience.
    110. (1998). Transplantation from donors whose hearts have stopped beating.
    111. (1996). Transplantation of kidneys from non-heart-beating donors: protocol, cardiac death diagnosis and results. Transpl
    112. (1996). Twelve years experience with nonheart-beating cadaveric donors.
    113. (1991). Twenty percent more kidneys through a nonheart beating program. Transpl
    114. (1993). Update o four experience in long-term renal function of kidneys transplanted from non-heartbeating cadáver donors. Transpl Proc.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.