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Regional Fibroblast Heterogeneity in the Lung: Implications for Remodeling

By Chakradhar Kotaru, Kathryn J. Schoonover, John B. Trudeau, Mai-Lan Huynh, XiuXia Zhou, Haizhen Hu and Sally E. Wenzel

Abstract

Rationale: Excessive deposition of extracellular matrix occurs in proximal airways of individuals with asthma, but fibrosis in distal lung has not been observed. Whether differing fibrotic capacities of fibroblasts from these two regions contribute to this variability is unknown

Topics: B. Asthma and Allergy
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2662967
Provided by: PubMed Central
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