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Imbalance between Cysteine Proteases and Inhibitors in a Baboon Model of Bronchopulmonary Dysplasia

By Ozden Altiok, Ryuji Yasumatsu, Gulbin Bingol-Karakoc, Richard J. Riese, Mildred T. Stahlman, William Dwyer, Richard A. Pierce, Dieter Bromme, Ekkehard Weber and Sule Cataltepe

Abstract

Rationale: Bronchopulmonary dysplasia (BPD) continues to be a major morbidity in preterm infants. The lung pathology in BPD is characterized by impaired alveolar and capillary development. An imbalance between proteases and protease inhibitors in association with changes in lung elastic fibers has been implicated in the pathogenesis of BPD

Topics: F. Pediatrics and Lung Development
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2662933
Provided by: PubMed Central
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