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Impaired Alveolar Macrophage Response to Haemophilus Antigens in Chronic Obstructive Lung Disease

By Charles S. Berenson, Catherine T. Wrona, Lori J. Grove, Jane Maloney, Mary Alice Garlipp, Paul K. Wallace, Carleton C. Stewart and Sanjay Sethi


Rationale: Interactions of nontypeable Haemophilus influenzae (NTHI) with macrophages are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immunologic mechanisms that mediate NTHI-macrophage inflammation are poorly understood. Outer membrane protein (OMP) P6 and lipooligosaccharide (LOS) of NTHI are potent immunomodulators. We theorized that alveolar macrophages in COPD possess fundamental immune defects that permit NTHI to evade host responses

Topics: C. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
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Provided by: PubMed Central
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