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Calcineurin Regulates Myocardial Function during Acute Endotoxemia

By Mandar S. Joshi, Mark W. Julian, Jennifer E. Huff, John A. Bauer, Yong Xia and Elliott D. Crouser


Rationale: Cyclosporin A (CsA) is known to preserve cardiac contractile function during endotoxemia, but the mechanism is unclear. Increased nitric oxide (NO) production and altered mitochondrial function are implicated as mechanisms contributing to sepsis-induced cardiac dysfunction, and CsA has the capacity to reduce NO production and inhibit mitochondrial dysfunction relating to the mitochondrial permeability transition (MPT)

Topics: C. Critical Care
Publisher: American Thoracic Society
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Provided by: PubMed Central
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