Skip to main content
Article thumbnail
Location of Repository

A Protective Role for the Fifth Complement Component (C5) in Allergic Airway Disease

By Scott M. Drouin, Meenal Sinha, Georgia Sfyroera, John D. Lambris and Rick A. Wetsel


Rationale: Reports from our laboratory, as well as those from others, have documented the importance of complement activation, the C3a anaphylatoxin, and its receptor, C3aR, in promoting Th2 effector functions in a mouse model of bronchopulmonary allergy. Although deficiency in the fifth complement component (C5) has been linked to enhanced airway hyperresponsiveness in mice, the contribution of C5 to other major biological hallmarks of asthma has not been evaluated

Topics: B. Asthma and Allergy
Publisher: American Thoracic Society
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.