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A Protective Role for the Fifth Complement Component (C5) in Allergic Airway Disease

By Scott M. Drouin, Meenal Sinha, Georgia Sfyroera, John D. Lambris and Rick A. Wetsel

Abstract

Rationale: Reports from our laboratory, as well as those from others, have documented the importance of complement activation, the C3a anaphylatoxin, and its receptor, C3aR, in promoting Th2 effector functions in a mouse model of bronchopulmonary allergy. Although deficiency in the fifth complement component (C5) has been linked to enhanced airway hyperresponsiveness in mice, the contribution of C5 to other major biological hallmarks of asthma has not been evaluated

Topics: B. Asthma and Allergy
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2662907
Provided by: PubMed Central
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