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Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase

By Inna E Tchivileva, Andrea G Nackley, Li Qian, Sean Wentworth, Matthew Conrad and Luda B Diatchenko
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2002). Activation of astrocyte intracellular signaling pathways by interleukin-1 in rat primary striatal cultures. Glia
  2. (1998). Ananko EA, Podkolodnaya OA, Kolpakov FA, et al.: Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res
  3. (2005). AS: Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression. Embo J
  4. (2004). Ashkenazi A: Tumor necrosis factor: an apoptosis JuNKie? Cell
  5. (1997). Breedveld FC: Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum
  6. (2001). Camandola S: NF-kappaB in neuronal plasticity and neurodegenerative disorders.
  7. (2002). Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis. Curr Drug Metab
  8. (2006). Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain
  9. (2007). Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain
  10. (2004). Cell type-specific interleukin-1beta signaling in the CNS.
  11. (1999). Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol Pharmacol
  12. (2004). Cho HJ: Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity.
  13. (2004). Chung LW: Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells.
  14. (1979). Creveling CR: Immunohistochemical demonstration of catechol-o-methyltransferase in mammalian brain. Brain Res
  15. (2003). Dahiya R: Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer. Cancer Res
  16. (2003). DR: Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience
  17. (2006). DR: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry
  18. (1976). Erythrocyte catechol-O-methyltransferase activity in facial pain patients. J Dent Res
  19. (2006). et al.: Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet
  20. (2002). Fang Y: Multiple transcription factor profiling by enzyme-linked immunoassay. Biotechniques
  21. (2004). Gaynor RB: IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci
  22. (2004). Geisslinger G: Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
  23. (2005). Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet
  24. (2000). GL: Cytokine involvement in dynorphin-induced allodynia. Pain
  25. (2007). Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain.
  26. (2002). Goeddel DV: TNF-R1 signaling: a beautiful pathway. Science
  27. (2003). Ho SL: Human catechol-O-methyltransferase down-regulation by estradiol. Neuropharmacology
  28. (2000). Hong JS: Reduction by naloxone of lipopolysaccharideinduced neurotoxicity in mouse cortical neuron-glia co-cultures. Neuroscience
  29. (1991). I: Cloning and characterization of human placental catechol-Omethyltransferase cDNA.
  30. (2005). Immune and glial cell factors as pain mediators and modulators. Exp Neurol
  31. (1998). Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res
  32. (2004). JA: Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.
  33. (2001). JC: Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms.
  34. (2005). JR: Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med
  35. (2007). JR: Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice. Neuroreport
  36. (1999). Kaakkola S: Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev
  37. (1997). Kaltschmidt C: NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci
  38. (1995). Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry
  39. (1996). KV: A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol
  40. (1998). Lap-Ping Y: Distribution of catecholO-methyltransferase expression in human central nervous system. Neuroreport
  41. (2007). Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat. Mol Ther
  42. (2000). Lin-Shiau SY: Activation of transcription factors of nuclear factor kappa B, activator protein-1 and octamer factors in hyperalgesia.
  43. (2005). LR: Central proinflammatory cytokines and pain enhancement. Neurosignals
  44. (2003). LR: Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
  45. (2001). Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide.
  46. (2002). Missing pieces in the NF-kappaB puzzle. Cell
  47. (2005). Modulation of peripheral inflammation in sensory ganglia by nuclear factor (kappa)B decoy oligodeoxynucleotide: involvement of SRC kinase pathway. Neurosci Lett
  48. (2000). NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today
  49. (1995). Panula P: Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein. Neurosci Lett
  50. (2006). Pathophysiology and treatment of pain in joint disease. Adv Drug Deliv Rev
  51. (2007). PJ: Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain.
  52. (2005). Quan N: Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
  53. (2004). Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett
  54. (1994). Rossomando EF: Tumor necrosis factor-alpha as a biochemical marker of pain and outcome in temporomandibular joints with internal derangements.
  55. (2006). SA: NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage
  56. (1993). Siebenlist U: Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci USA
  57. (2005). Signaling via NF-kappaB in the nervous system. Biochim Biophys Acta
  58. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol
  59. (1994). SM: GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801. Exp Neurol
  60. (2003). Sommer C: Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies. Acta Neuropathol
  61. (2006). SR: Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.
  62. (2006). Tawfik VL, LaCroix-Fralish ML: The tetrapartite synapse: path to CNS sensitization and chronic pain. Pain
  63. (1958). Tomchik R: O-methylation of catechol amines in vivo.
  64. (1995). Ulmanen I: Cloning, expression and structure of catechol-Omethyltransferase. Biochim Biophys Acta
  65. (1994). Ulmanen I: Genomic organization of the human catechol Omethyltransferase gene and its expression from two distinct promoters.
  66. (1990). Ulmanen I: Molecular cloning and characterization of rat liver catechol-O-methyltransferase. Gene
  67. (1993). Ulmanen I: Structure of the rat catechol-O-methyltransferase gene: separate promoters are used to produce mRNAs for soluble and membrane-bound forms of the enzyme.
  68. (2007). XG: Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha

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